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Reactive Arial-based Antitachycardia Pacing Therapy Reduces Atrial Tachyarrhthmias
(PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2019-07)
Background Reactive atrial-based antitachycardia pacing (rATP) aims to terminate atrial tachyarrhythmia/atrial fibrillation (AT/AF) episodes when they spontaneously organize to atrial flutter or atrial tachycardia; however, ...
Low-grade albuminuria in pulmonary arterial hypertension
(PULMONARY CIRCULATION, 2019-06)
Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to ...
Low-Dose Aspirin for Primary Prevention of Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study
(2019-12-17)
Background
Data are limited on use patterns of low-dose aspirin and its role for primary prevention of cardiovascular disease (CVD) in different racial and ethnic groups.
Methods and Results
Overall, 65 231 ...
Rationale and design of the EMPERIAL-Preserved and EMPERIAL-Reduced trials of empagliflozin in patients with chronic heart failure
(European Journal of Heart Failure, 2019-07)
Aims Heart failure ( HF) is associated with considerable symptom burden and impairment in physical functioning and quality of life. The sodium-glucose co-transporter 2 inhibitor empagliflozin reduced the risk of HF ...
Interaction of alpha Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury
(Journal of the American Heart Association, 2019-08-20)
Background-alpha Carboxyl terminus 1 (alpha CT1) is a 25-amino acid therapeutic peptide incorporating the zonula occludens-1 (ZO-1)-binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on ...
Natural History of Cardiomyopathy in Adult Dogs With Golden Retriever Muscular Dystrophy
(Journal of the American Heart Association, 2019-08-20)
Background-Duchenne muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness. Affected boys typically die from respiratory or cardiac failure. Golden retriever muscular dystrophy (GRMD) is ...
Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study
(Journal of the American Heart Association, 2019-03-19)
Background-Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins.
Methods and Results-We performed proteomics assays among participants from the Framingham Heart Study Offspring ...
Echocardiographic Detection of Occult Diastolic Dysfunction in Pulmonary Hypertension After Fluid Challenge
(Journal of the American Heart Association, 2019-09-23)
Background-Identification of occult diastolic dysfunction often requires invasive right heart catheterization with provocative maneuvers such as fluid challenge. Non-invasive predictors of occult diastolic dysfunction have ...
Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects
(Circulation, 2019-07-23)
Background: Drug effects can be investigated through natural variation in the genes for their protein targets. The present study aimed to use this approach to explore the potential side effects and repurposing potential ...
Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials
(European Journal of Heart Failur, 2019-09)
Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. ...