RSS 1.0Research reports
Browse by
Recent Submissions
-
(The Journal of Infectious Diseases, 2019-08-01)Metabolic complications relating to complex effects of viral and immune-mediated mechanisms are now a focus of clinical care among persons living with human immunodeficiency virus (PLHIV), and obesity is emerging as a ...
-
(Scientific Reports, 2019-07-16)As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...
-
(Frontiers in Bioengineering and Biotechnology, 2019-09-20)The extensive application of engineered nanomaterial (ENM) in various fields increases the possibilities of human exposure, thus imposing a huge risk of nanotoxicity. Hence, there is an urgent need for a detailed risk ...
-
(Frontiers in Immunology, 2019-09-25)Our previous studies of protective immunity and pathology against blood stage malaria parasites have shown that not only CD4(+) T cells, but also CD8(+) T cells and macrophages, are important for host defense against blood ...
-
(FRONTIERS IN MICROBIOLOGY, 2019-07-23)Acinetobacter baumannii A118, a strain isolated from the blood of an infected patient, is naturally competent and unlike most clinical strains, is susceptible to a variety of different antibiotics including those usually ...
-
(PLOS COMPUTATIONAL BIOLOGY, 2019-04)The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to ...
-
(eLife, 2019-03-27)Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study ...
-
(Cancer Iinformatics, 2019-04-16)The genome-wide identification of mutated genes is an important advance in our understanding of tumor biology, but several fundamental questions remain open. How do these genes act together to promote cancer development ...
-
(2019-03)The gastric bacterium Helicobacter pylori causes a persistent infection that is directly responsible for gastric ulcers and gastric cancer in some patients and protective against allergic and other immunological disorders ...
-
(MBIO, 2019-03)Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these components lends spatial organization to ...
-
(MBIO, 2019-05)Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma; however, most infected individuals never develop this malignancy. Strain-specific microbial factors, such as the oncoprotein CagA, as well as ...
-
(NATURE COMMUNICATIONS, 2019-07-09)Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a ...
-
(OPEN FORUM INFECTIOUS DISEASES, 2019-04)
-
(NATURE COMMUNICATIONS, 2019-07-10)TFF1, a secreted protein, plays an essential role in keeping the integrity of gastric mucosa and its barrier function. Loss of TFF1 expression in the TFF1-knockout (KO) mouse leads to a pro-inflammatory phenotype with a ...