Browsing Vanderbilt University Medical Center by Title
Now showing items 137-156 of 315
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(Cancer Iinformatics, 2019-04-16)The genome-wide identification of mutated genes is an important advance in our understanding of tumor biology, but several fundamental questions remain open. How do these genes act together to promote cancer development ...
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(JACC-Heart Failure, 2020-03)Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working group's objective ...
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Interventions to prevent iatrogenic anemia: a Laboratory Medicine Best Practices systematic review (Critical Care, 2019-08-09)Background As many as 90% of patients develop anemia by their third day in an intensive care unit (ICU). We evaluated the efficacy of interventions to reduce phlebotomy-related blood loss on the volume of blood lost, ...
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Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG (Frontiers In Microbiology, 2023-01-04)IntroductionIntestinal epithelial cells (IECs) provide the frontline responses to the gut microbiota for maintaining intestinal homeostasis. Our previous work revealed that IEC-derived components promote the beneficial ...
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(Critical Care, 2019-07-23)BackgroundIntravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial ...
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(Journal of the American Heart Association, 2019-06-18)
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(Arthritis Research & Therapy, 2019-06-25)BackgroundGATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. ...
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(Arthritis Research & Therapy, 2019-06-25)BackgroundGATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. ...
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(INTENSIVE CARE MEDICINE, 2019-07)ObjectiveTo identify the key mechanisms that clinicians perceive improve care in the intensive care unit (ICU), as a result of their involvement in post-ICU programs.MethodsQualitative inquiry via focus groups and interviews ...
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(Frontiers in Psychiatry, 2019-07-25)Background: Many individuals with autism spectrum disorder (ASD) have significant gastrointestinal (GI) symptoms, but their etiology is currently unknown. Dietary interventions are common in children and adolescents with ...
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(SUPPORTIVE CARE IN CANCER, 2019-08)PurposeNeuroinflammation and central sensitization from cancer and its therapy may result in chronic systemic symptoms (CSS) such as fatigue, sleep disturbance, chronic widespread pain, mood disorders, neuropsychiatric ...
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(Cellular and Molecular Gastroenterology and Hepatlogy, 2020)
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(Scientific Reports, 2019-07-16)As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...
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(2015)Case: An immune competent pediatric patient presented with a persistent lower extremity infection with Leclercia adecarboxylata after a penetrating injury. This case report details the presentation, clinical course, and ...
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(ELIFE, 2022-12-02)An important question in organogenesis is how tissue-specific transcription factors interact with signaling pathways. In some cases, transcription factors define the context for how signaling pathways elicit tissue- or ...
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(American Journal of Epidemiology, 2019-12)Improvements in life expectancy among people living with human immunodeficiency virus (PLWH) receiving antiretroviral treatment in the United States and Canada might differ among key populations. Given the difference in ...
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(International Journal Of Molecular Sciences, 2022-12-26)Scientists have long established that fatty acids are the primary substrates for kidney mitochondria. However, to date we still do not know how long-chain and middle-chain fatty acids are oxidized at the mitochondrial ...
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(International Journal of Pedicatrics, 2019)Introduction. Child mortality rate in sub-Saharan Africa is 29 times higher than that in industrialized countries. Anemia is one of the preventable causes of child morbidity. During a humanitarian medical mission in rural ...
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(Journal of Infectious Diseases, 2020-03-01)Background. Multiple factors influence the human immunodeficiency virus (HIV) antibody response produced during natural infection, leading to responses that can vary in specificity, strength, and breadth. Methods. People ...
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(2019-12-17)Background Data are limited on use patterns of low-dose aspirin and its role for primary prevention of cardiovascular disease (CVD) in different racial and ethnic groups. Methods and Results Overall, 65 231 ...