| dc.contributor.author | Fernandez-Jimenez, Rodrigo | |
| dc.contributor.author | Wang, Thomas J. | |
| dc.contributor.author | Fuster, Valentin | |
| dc.contributor.author | Blot, William J. | |
| dc.date.accessioned | 2020-10-22T15:14:17Z | |
| dc.date.available | 2020-10-22T15:14:17Z | |
| dc.date.issued | 2019-12-17 | |
| dc.identifier.citation | Journal of the American Heart Association | en_US |
| dc.identifier.issn | 2047-9980 | |
| dc.identifier.uri | http://hdl.handle.net/1803/16241 | |
| dc.description.abstract | Background
Data are limited on use patterns of low-dose aspirin and its role for primary prevention of cardiovascular disease (CVD) in different racial and ethnic groups.
Methods and Results
Overall, 65 231 non-Hispanic black and white people aged 40 to 79 years with no history of CVD enrolled from 2002 through 2009 in the SCCS (Southern Community Cohort Study). At cohort entry, the simplified Framingham 10-year CVD risk was calculated, and data related to low-dose aspirin use and clinical and socioeconomic covariates were collected. Race- and ethnicity-specific adjusted odds ratios for characteristics of low-dose aspirin users and hazard ratios for ischemic cardiac death according to aspirin use were calculated using multivariate logistic and Cox regression models. Black participants were less likely to take low-dose aspirin compared with white participants, regardless of CVD risk and covariates (adjusted odds ratio: 0.79; 95% CI, 0.75-0.82). Over a median follow-up of 11.3 years, low-dose aspirin use was associated with a trend toward decreased risk of ischemic cardiac death in white participants (adjusted hazard ratio: 0.86; 95% CI, 0.68-1.10), especially in women (adjusted hazard ratio: 0.72; 95% CI, 0.51-1.02), but not in black participants (adjusted hazard ratio: 1.18; 95% CI, 0.98-1.40). Similar trends were observed when the analysis was restricted to high-risk individuals aged 50 to 69 or 50 to 59 years, ages for which guidelines consider aspirin for CVD primary prevention.
Conclusions
Low-dose aspirin use for primary prevention of CVD is lower among black than white patients. Its use might be associated with a disparate impact on ischemic cardiac death according to race and ethnicity. Although additional studies are required, these findings provide no evidence of a beneficial effect of aspirin among black patients for CVD primary prevention. | en_US |
| dc.description.sponsorship | The SCCS (Southern Community Cohort Study) is funded by grants R01 CA092447 and U01 CA202979 from the National Cancer Institute, including American Recovery and Reinvestment Act funding (3R01 CA029447-08 51). Data collection was performed by the Survey and Biospecimen Shared Resource, which is supported in part by the VanderbiltIngram Cancer Center (P30 CA68485). This analysis forms part of a project that has received funding from the American Heart Association under grant no. 14SFRN20490315. Fernandez-Jimenez is a recipient of funding from the European Union Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie grant agreement no. 707642. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Instituto de Salud Carlos Ill; the Ministerio de Ciencia, Innovacion y Universidades; and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | en_US |
| dc.language.iso | en_US | en_US |
| dc.rights | ª 2019 The Authors. Published on behalf of the American Heart Association,
Inc., by Wiley. This is an open access article under the terms of the Creative
Commons Attribution-NonCommercial-NoDerivs License, which permits use
and distribution in any medium, provided the original work is properly cited,
the use is non-commercial and no modifications or adaptations are made. | |
| dc.source.uri | https://www.ahajournals.org/doi/10.1161/JAHA.119.013404 | |
| dc.subject | aspirin | en_US |
| dc.subject | ethnicity | en_US |
| dc.subject | ischemic heart disease | en_US |
| dc.subject | primary prevention | en_US |
| dc.title | Low-Dose Aspirin for Primary Prevention of Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1161/JAHA.119.013404 | |
