dc.contributor.author | Tierney, Jaime | |
dc.contributor.author | Baker, Jennifer | |
dc.contributor.author | Borgmann, Anthony | |
dc.contributor.author | Brown, Daniel | |
dc.contributor.author | Byram, Brett | |
dc.date.accessioned | 2020-08-20T00:47:04Z | |
dc.date.available | 2020-08-20T00:47:04Z | |
dc.date.issued | 2019-09-10 | |
dc.identifier.citation | Tierney, J., Baker, J., Borgmann, A., Brown, D., & Byram, B. (2019). Non-contrast power Doppler ultrasound imaging for early assessment of trans-arterial chemoembolization of liver tumors. Scientific reports, 9(1), 13020. https://doi.org/10.1038/s41598-019-49448-8 | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/1803/10387 | |
dc.description.abstract | Trans-arterial chemoembolization (TACE) is an important yet variably effective treatment for management of hepatic malignancies. Lack of response can be in part due to inability to assess treatment adequacy in real-time. Gold-standard contrast enhanced computed tomography and magnetic resonance imaging, although effective, suffer from treatment-induced artifacts that prevent early treatment evaluation. Non-contrast ultrasound is a potential solution but has historically been ineffective at detecting treatment response. Here, we propose non-contrast ultrasound with recent perfusion-focused advancements as a tool for immediate evaluation of TACE. We demonstrate initial feasibility in an 11-subject pilot study. Treatment-induced changes in tumor perfusion are detected best when combining adaptive demodulation (AD) and singular value decomposition (SVD) techniques. Using a 0.5 s (300-sample) ensemble size, AD + SVD resulted in a 7.42 dB median decrease in tumor power after TACE compared to only a 0.06 dB median decrease with conventional methods. | en_US |
dc.description.sponsorship | The authors would like to thank the staff of the Vanderbilt University ACCRE computing resource. This work was supported in part by NIH grants 1R35HL135790-01 and S10OD016216-01 and NSF award IIS-1750994. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Scientific Reports | en_US |
dc.rights | Copyright © The Author(s) 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736854/ | |
dc.title | Non-contrast power Doppler ultrasound imaging for early assessment of trans-arterial chemoembolization of liver tumors | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41598-019-49448-8 | |