• Effects of cell size and bicarbonate on single photon response variability in retinal rods 

  Geva, Polina; Caruso, Giovanni; Klaus, Colin; Hamm, Heidi E; Gurevich, Vsevolod V.; DiBenedetto, Emmanuele; Makino, Clint L. (Frontiers In Molecular Neuroscience, 2022-12-14)

  Accurate photon counting requires that rods generate highly amplified, reproducible single photon responses (SPRs). The SPR is generated within the rod outer segment (ROS), a multilayered structure built from membranous ...
• REPLY TO TRAN ET AL.: Dimeric KRAS protein-protein interaction stabilizers 

  Moser, Franziska; Phan, Jason; Sai, Jiqing; Sun, Qi; Waterson, Alex; Fesik, Stephen W. (Proceedings of the National Academy of Sciences of the United States of America, 2020-02-18)
• Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure 

  Morgan, Thomas (Nature Communications, 2020-01-09)

  Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded ...
• A network analysis to identify mediators of germline-driven differences in breast cancer prognosis 

  Blot, William (Nature Communications, 2020-01-16)

  Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential ...
• Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study 

  Gwirtsman, Harry E. (Nature Communications, 2020-02-03)

  Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known ...
• Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility 

  Aldrich, Melinda C. (Nature Communications, 2020-01-07)

  Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and ...
• Interactive Multiresolution Visualization of Cellular Network Processes 

  Ortega, Oscar O.; Lopez, Carlos F. (iScience, 2020-01-24)

  Visualization plays a central role in the analysis of biochemical network models to identify patterns that arise from reaction dynamics and perform model exploratory analysis. To facilitate these analyses, we developed ...
• Countermanding Perceptual Decision-Making 

  Middlebrooks, Paul G.; Zandbelt, Bram B.; Logan, Gordon D.; Palmeri, Thomas J.; Schall, Jeffrey D. (iScience, 2020-01-24)

  We investigated whether a task requiring concurrent perceptual decision-making and response control can be performed concurrently, whether evidence accumulation and response control are accomplished by the same neurons, ...
• Profiling of the plasma proteome across different stages of human heart failure 

  Wells, Quinn S. (Nature Communications, 2019-12-20)

  Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may ...
• Can Mentoring Promote Self-esteem and School Connectedness? An Evaluation of the Mentor-UP Project 

  Marino, Claudia; Santinello, Massimo; Lenzi, Michela; Santoro, Paolo; Bergamin, Marisa; Gaboardi, Marta; Calcagni, Antonio; Altoe, Gianmarco; Perkins, Douglas D. (Psychological Inervention, 2020-04)

  Research in the United States has shown that youth mentoring is a promising strategy for increasing self-esteem and school connectedness in at-risk youth. There has been little confirmation of those findings internationally. ...
• GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations 

  Petty, Lauren E.; Below, Jennifer E. (PLoS One, 2019-06-28)

  Background The electrocardiographically quantified QRS duration measures ventricular depolarization and conduction. QRS prolongation has been associated with poor heart failure prognosis and cardiovascular mortality, ...
• Innate CD8 alpha alpha(+) cells promote ILC1-like intraepithelial lymphocyte homeostasis and intestinal inflammation 

  Nazmi, Ali; Hoek, Kristen L.; Greer, Michael J.; Piazuelo, Maria B.; Minato, Nagahiro; Olivares-Villagomez, Danyvid (PLoS One, 2019-07-10)

  Innate CD8 alpha alpha(+) cells, also referred to as iCD8 alpha cells, are TCR-negative intraepithelial lymphocytes (IEL) possessing cytokine and chemokine profiles and functions related to innate immune cells. iCD8 alpha ...
• Engaging policy in science writing: Patterns and strategies 

  Ruhl, J. B.; Posner, Stephen M.; Ricketts, Taylor H. (PLoS One, 2019-08-01)

  Many scientific researchers aspire to engage policy in their writing, but translating scientific research and findings into policy discussion often requires an understanding of the institutional complexities of legal and ...
• Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways 

  Cheung-Flynn, Joyce; Alvis, Bret D.; Hocking, Kyle M.; Guth, Christy M.; Luo, Weifeng; McCallister, Reid; Chadalavada, Kalyan; Polcz, Monica; Komalavilas, Padmini; Brophy, Colleen M. (PLoS One, 2019-08-14)

  Resuscitation with 0.9% Normal Saline (NS), a non-buffered acidic solution, leads to increased morbidity and mortality in the critically ill. The goal of this study was to determine the molecular mechanisms of endothelial ...
• Abnormal sodium and water homeostasis in mice with defective heparan sulfate polymerization 

  Engberink, Rik H. G. Olde; de Vos, Judith; van Weert, Angela; Zhang, Yahua; van Vlies, Naomi; van den Born, Bert-Jan H.; Titze, Jens M.); van Bavel, Ed; Vogt, Liffert (PLoS One, 2019-07-31)

  Glycosaminoglycans in the skin interstitium and endothelial surface layer have been shown to be involved in local sodium accumulation without commensurate water retention. Dysfunction of heparan sulfate glycosaminoglycans ...
• Association between alcohol use and inflammatory biomarkers over time among younger adults with HIV-The Russia ARCH Observational Study 

  Freiberg, Matthew S. (PLoS One, 2019-08-22)

  Background Biomarkers of monocyte activation (soluble CD14 [sCD14]), inflammation (interleukin-6 [IL-6]), and altered coagulation (D-dimer) are associated with increased mortality risk in people with HIV. The objective ...
• Primary care physicians' perceptions of barriers and facilitators to management of chronic kidney disease: A mixed methods study 

  Abdel-Kader, Khaled; Cavanaugh, Kerri (PLoS One, 2019-08-22)

  Background Given the high prevalence of chronic kidney disease (CKD), primary care physicians (PCPs) frequently manage early stage CKD. Nonetheless, there are challenges in providing optimal CKD care in the primary care ...
• The long-term consequences of antibiotic therapy: Role of colonic short-chain fatty acids (SCFA) system and intestinal barrier integrity 

  Holota, Yuliia; Dovbynchuk, Taisa; Kaji, Izumi; Vareniuk, Igor; Dzyubenko, Natalia; Chervinska, Tetiana; Zakordonets, Liudmyla; Stetska, Viktoria; Ostapchenko, Liudmyla; Serhiychuk, Tetiana; Tolstanova, Ganna (PLoS One, 2019-08-22)

  Epidemiological studies revealed that antibiotics exposure increases a risk of inflammatory bowel diseases (IBD) development. It remained largely unknown how antibiotic-induced dysbiosis confers the risk for enhanced ...
• Zinc deficiency and advanced liver fibrosis among HIV and hepatitis C co-infected anti-retroviral naive persons with alcohol use in Russia 

  Barocas, Joshua A.; So-Armah, Kaku; Cheng, Debbie M.; Lioznov, Dmitry; Baum, Marianna; Gallagher, Kerrin; Fuster, Daniel; Gnatienko, Natalia; Krupitsky, Evgeny; Freiberg, Matthew S.; Samet, Jeffrey H. (PLoS One, 2019-06-27)

  Background and aims Liver disease in people living with HIV co-infected with hepatitis C virus is a source of morbidity and mortality in Russia. HIV accelerates liver fibrosis in the setting of HCV co-infection and ...
• Multi-scale, numerical modeling of spatio-temporal signaling in cone phototransduction 

  Klaus, Colin; Caruso, Giovanni; Gurevich, Vsevolod V.; DiBenedetto, Emmanuele (2019-07-25)

  Mammals have two types of photoreceptors, rods and cones. While rods are exceptionally sensitive and mediate vision at very low illumination levels, cones operate in daylight and are responsible for the bulk of visual ...

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