dc.contributor.author | Antunes, Krist Helen | |
dc.contributor.author | Fachi, Jose Luis | |
dc.contributor.author | de Paula, Rosemeire | |
dc.contributor.author | da Silva, Emanuelle | |
dc.contributor.author | Pral, Lais Passariello | |
dc.contributor.author | dos Santos, Adara Aurea | |
dc.contributor.author | Dias, Greicy Brisa Malaquias | |
dc.contributor.author | Vargas, Jose Eduardo | |
dc.contributor.author | Puga, Renato | |
dc.contributor.author | Mayer, Fabiana Quoos | |
dc.date.accessioned | 2020-06-19T17:38:26Z | |
dc.date.available | 2020-06-19T17:38:26Z | |
dc.date.issued | 2019-07-22 | |
dc.identifier.citation | Antunes, K.H., Fachi, J.L., de Paula, R. et al. Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat Commun 10, 3273 (2019). https://doi.org/10.1038/s41467-019-11152-6 | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/1803/10057 | |
dc.description.abstract | Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-beta (IFN-beta) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary epithelial cells reduced virus-induced cytotoxicity and promoted antiviral effects through IFN-beta response. The effect of acetate on RSV infection was abolished in Gpr43(-/-) mice. Our findings reveal antiviral effects of acetate involving IFN-beta in lung epithelial cells and engagement of GPR43 and IFNAR. | en_US |
dc.description.sponsorship | We thank Gessica Antunes and Janaina Pasetti for technical assistance. This study was supported by Sao Paulo Research Foundation (FAPESP, 2012/10653-9; 2013/06810-4; 2017/06577-9), FAPERGS (17/2551-0001 380-8), National Council for Scientific and Technological Development (CNPq) (036270/2016), and Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES)-Finance Code 001. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Communications | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.source.uri | https://www.nature.com/articles/s41467-019-11152-6#citeas | |
dc.subject | CHAIN FATTY-ACIDS | en_US |
dc.subject | GUT MICROBIOTA | en_US |
dc.subject | DIETARY FIBER | en_US |
dc.subject | INFLAMMATORY RESPONSES | en_US |
dc.subject | VIRAL BRONCHIOLITIS | en_US |
dc.subject | INNATE IMMUNITY | en_US |
dc.subject | GENE | en_US |
dc.subject | SUSCEPTIBILITY | en_US |
dc.subject | CELLS | en_US |
dc.subject | RSV | en_US |
dc.title | Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41467-019-11152-6 | |