Now showing items 1-10 of 10

    • Linton, MacRae F.; Moslehi, Javid J.; Babaev, Vladimir R. (International Journal of Molecular Sciences, 2019-06-01)
      The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
    • Kesler, Benjamin; Li, Guoliang; Thiemicke, Alexander; Venkat, Rohit; Neuert, Gregor (Scientific Reports, 2019-07-15)
      To characterize cell types, cellular functions and intracellular processes, an understanding of the differences between individual cells is required. Although microscopy approaches have made tremendous progress in imaging ...
    • Wilson, Blake A.; Ramanathan, Arvind; Lopez, Carlos F. (Biophysical Journal, 2019-08)
      Cardiolipin is an anionic lipid found in the mitochondrial membranes of eukaryotes ranging from unicellular microorganisms to metazoans. This unique lipid contributes to various mitochondrial functions, including metabolism, ...
    • Ferguson, Michael A.; Lim, Chun; Cooke, Danielle; Darby, R. Ryan; Wu, Ona; Rost, Natalia S.; Corbetta, Maurizio; Grafman, Jordan; Fox, Michael D. (NATURE COMMUNICATIONS, 2019-08-02)
      Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of ...
    • Phillips, Elizabeth Jane; Mallal, Simon Alexander (Nature Communications, 2019-08-08)
      Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate ...
    • Weissmiller, April M.; Wang, Jing; Lorey, Shelly L.; Howard, Gregory C.; Martinez, Ernest; Liu, Qi; Tansey, William P. (Nature Communications, 2019-05-01)
      SMARCB1 encodes the SNF5 subunit of the SWI/SNF chromatin remodeler. SNF5 also interacts with the oncoprotein transcription factor MYC and is proposed to stimulate MYC activity. The concept that SNF5 is a coactivator for ...
    • Creed, Jordan H.; Peeri, Noah C.; Anic, Gabriella M.; Thompson, Reid C.; Olson, Jeffrey J.; LaRocca, Renato, V.; Chowdhary, Sajeel A.; Brockman, John D.; Gerke, Travis A.; Nabors, Louis B.; Egan, Kathleen M. (Scientific Reports, 2019-07-26)
      Methylmercury (MeHg) is an environmental neurotoxin with human exposure mainly from dietary intake of contaminated fish. Exposure to MeHg has been implicated in neurological damage, but research on its role in cancers, ...
    • Antunes, Krist Helen; Fachi, Jose Luis; de Paula, Rosemeire; da Silva, Emanuelle; Pral, Lais Passariello; dos Santos, Adara Aurea; Dias, Greicy Brisa Malaquias; Vargas, Jose Eduardo; Puga, Renato; Mayer, Fabiana Quoos (Nature Communications, 2019-07-22)
      Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on ...
    • Euliano, Erin M.; Hardcastle, Austin N.; Victoriano, Christie M.; Gabella, William E.; Haselton, Frederick R.; Adams, Nicholas M. (Scientific Reports, 2019-08-06)
      Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for the molecular diagnosis of many infectious diseases, including RNA viruses, but is generally limited to settings with access to trained ...
    • Yan, Wei; Li, Kai; Buhe, Amin; Li, Tianxiong; Tian, Peirong; Hong, Jun (RSC Advances, 2019-08-18)
      The endoplasmic reticulum stress (ERS)-induced autophagy and apoptosis are favorable for the suppression of many cancer types. Salidroside (Salid) has been proven to be capable of inducing the apoptosis of many cancer ...