Browsing by Subject "Drosophila"
Now showing items 1-19 of 19
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(2007-12-17)Department: Biological SciencesFragile X Syndrome (FXS) is the most common form of inherited mental retardation. In this thesis, I describe my work using a Drosophila model to study cellular, molecular and genetic mechanisms that underlie the cognitive ...
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(2022-02-16)Department: Cell & Developmental BiologyWhen an organism is injured, the damaged tissue recognizes the presence and severity of the wound and rapidly responds to repair the injury and restore proper tissue functionality. But how do cells first detect the presence ...
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(2017-04-05)Department: PhysicsIn the series of morphogenetic events that are required for Drosophila development, some of the most dramatic are those that involve the coordinated movement of the germband and amnioserosa, two epithelia that remain ...
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(2019-03-22)Department: Cell and Developmental BiologyThe basement membrane is a sheet-like extracellular matrix that wraps around muscle fibers and underlies epithelia. Although the basement membrane is often considered to be static, there are indications that the BM is a ...
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(2018-09-20)Department: PhysicsThis work applies novel inverse modeling techniques to both chemical kinetics in lab-on-chip devices and cell mechanics in developing Drosophila embryos. The aim is to describe these systems quantitatively; to compare ...
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(2010-03-29)Department: NeuroscienceRolling Blackout (RBO), a Drosophila EFR3 homolog, is an integral membrane protein predicted to be a lipase. A conditional temperature-sensitive (TS) mutant (rbots) displays paralysis following a 25-37oC temperature shift, ...
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(2010-08-04)Department: Biological SciencesA systematic Drosophila forward genetic screen for photoreceptor synaptic transmission mutants identified no-on-and-no-off transient C (nonC) based on loss of retinal synaptic responses to light stimulation. The cloned ...
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(2020-02-17)Department: Biological SciencesIn the nervous system, Wnts act as potent regulators of synaptic connectivity, architecture, neurotransmission strength and activity-dependent plasticity. As the founding Wnt, Drosophila Wingless (Wg) has key roles at the ...
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(2010-08-05)Department: Cell and Developmental BiologyMutations in human microcephalin (MCPH1) result in a form of autosomal recessive primary microcephaly, a disorder of fetal brain growth characterized by a severely reduced cerebral cortex and head size with mental retardation. ...
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(2015-03-25)Department: Electrical EngineeringThis thesis demonstrates the feasibility of designing and building a Drosophila automated training and testing system for Pavlovian classical associative learning/memory analyses using inexpensive hardware and software ...
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(2011-11-22)Department: Biological SciencesFragile X syndrome, resulting from the loss of function of the hFMR1 gene, is the most common heritable cause of intellectual disability. The human genome also encodes two closely related paralogs: hFXR1 and hFXR2. Drosophila ...
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(2015-04-02)Department: PhysicsMapping the forces responsible for morphogenetic movements in embryonic Drosophila melanogaster, or the fruit fly, is the focus of this thesis, specifically studying cellular pulsations and laser ablation wounds in the ...
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(2015-07-07)Department: PhysicsEnvironmental perturbations can disrupt development by altering both the molecular dynamics as well as tissue- and cell-level mechanics. Specifically, a heat shock administered in early Drosophila embryogenesis can result ...
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(2014-08-18)Department: Cell and Developmental BiologyIn a biochemical screen Anaphase-Promoting Complex (APC) substrates, we identified Drosophila MCPH1 isoform B (dMCPH1-B) as a substrate of APCCdh1. dMCPH1-B undergoes Cdh1-dependent degradation in Xenopus egg extract, which ...
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(2011-07-25)Department: Cell and Developmental BiologyIn a screen for cell-cycle regulators, we identified a Drosophila maternal effect-lethal mutant that we named “no poles” (nopo). Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles ...
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(2009-09-22)Department: Cell and Developmental BiologyDynein is a minus-end directed microtubule motor complex that is required for a diverse range of biological processes, from intracellular-cargo transport to cell migration. Dynein is regulated at multiple levels and its ...
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(2006-11-27)Department: PharmacologyThe transient receptor potential (TRP) ion channels are implicated in diverse physiological processes, however their regulatory mechanisms remain obscure. In Drosophila, TRP is a calcium channel mediating the light-dependent ...
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(2020-02-18)Department: Biological SciencesMicrobe-animal symbioses are ubiquitous in nature. Microbes of particular host tissues often have unique functions or effects on the host. Within arthropods, microorganisms of the reproductive tissues may have profound ...
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(2008-12-29)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY THE ROLE OF α-ENDOSULFINE IN THE FEMALE MEIOTIC CELL CYCLE IN DROSOPHILA JESSICA R. VON STETINA Dissertation under the direction of Professor Daniela Drummond-Barbosa Meiosis is coupled ...