Browsing by Subject "DNA damage"
Now showing items 1-18 of 18
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Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA) (2013-07-12)Department: BiochemistryThe in vivo analysis of dynamic events that protect genomic and epigenomic integrity during DNA replication has been a challenging task. The proteins that ensure the accurate inheritance of the genome act directly at ...
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(2015-10-06)Department: Cell and Developmental BiologyProteins of the Bcl-2 family mediate apoptosis by altering mitochondrial structure, function, and integrity. However, in certain contexts, some members of the Bcl-2 family have additional, non-apoptotic functions. Bid, a ...
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(2005-11-02)Department: BiochemistryTopoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...
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(2010-04-30)Department: BiochemistryDiepoxybutane is a mutagenic and carcinogenic oxidation product of the important industrial chemical and environmental contaminant butadiene. The mutagenic potential of diepoxybutane is thought to be due in part to its ...
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(2018-11-21)Department: BiochemistryThe ATR kinase controls cell cycle transitions and the DNA damage response. Budding yeast contain three activators of Mec1ATR; however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication ...
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(2018-09-18)Department: BiochemistryThe preservation of DNA replication is requisite for cellular integrity and prevention of tumor formation and cell death. The Y-family DNA polymerases (Pol eta, kappa, iota, and REV1) are crucial in this process because ...
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(2006-12-07)Department: BiochemistryBIOCHEMISTRY IDENTIFICATION AND REGULATION OF P53 TARGET GENES IN PRIMARY HUMAN EPIDERMAL KERATINOCYTES KRISTY L. SCHAVOLT Dissertation under the direction of Professor Jennifer A. Pietenpol The p53 tumor suppressor ...
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(MBIO, 2019-05)Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma; however, most infected individuals never develop this malignancy. Strain-specific microbial factors, such as the oncoprotein CagA, as well as ...
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(Biomedicine & Pharmacotherapy, 2022-12-06)Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. ...
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(2011-09-07)Department: Cancer BiologyUnderstanding how cells maintain genome integrity is necessary to gain insight into the pathology of cancer and to identify therapeutic targets and biomarkers. The DNA damage response kinase ATR is essential for the ...
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(2011-09-02)Department: Cell and Developmental BiologyFirst identified as a pro-apoptotic member in the programmed cell death pathway, BH3 interacting domain death agonist (BID) has recently been demonstrated to play a role to maintain genomic integrity and execute DNA damage ...
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(2018-07-11)Department: Cell and Developmental BiologyThe DNA damage response consists of complex signaling pathways that act to recognize and remove various types of genomic insults. One particularly dangerous type of lesion is an interstrand cross-link (ICL). ICLs are ...
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(2016-08-03)Department: ChemistryDamage to DNA results from many endogenous and exogenous sources and plays a significant role in cancer etiology. 3-Nitrobenzathrone (3-NBA) is a component of diesel exhaust that is known to form DNA adducts. Aminobenzanthrone ...
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(2008-06-06)Department: ChemistryThis dissertation involves the structural and equilibrium studies of three DNA lesions: aflatoxin B1 formamidopyrimidine, methyl formamidopyrimidine, and thymine glycol. Studies of the methyl formamidopyrimidine ...
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(2015-11-27)Department: Chemical and Physical BiologyChemical and Physical Biology Structures of the 3,4-Epoxybutene-Derived R- and S-N1-(2-Hydroxy-buten-2-yl) -2' Deoxyinosine DNA Adducts: Regiochemical Control of Glycosidic Torsion Angle Conformation Dennis Kuo Thesis ...
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(2007-10-08)Department: ChemistryMethylating agents react with DNA to give the cationic N7-methyl deoxyguanosine adduct, which can undergo hydrolytic opening of the imidazole ring to form 2,6-diamino-4-hydroxy-N5-(methyl)-formamido-pyrimidine (MeFAPy-dGuo) ...
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(Vanderbilt University. Medical Center, 2007-07-06)
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(2019-09-16)Department: Biological SciencesDNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. In addition to maintaining telomeres, telomerase can act on DSBs creating de novo telomeres, a mutagenic ...