Browsing by Department "Pathology"
Now showing items 1-20 of 44
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(2014-08-04)Department: PathologyCystic fibrosis (CF) is a debilitating, multi-organ, autosomal recessive disease caused by mutations leading to absence of functional cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial cells. Chronic ...
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(2014-04-19)Department: PathologyFactor XI (FXI) is the zymogen of a protease (FXIa) that contributes to blood coagulation by activating factor IX (FIX). This thesis presents several novel observations regarding the structure and function of FXI that will ...
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(2007-06-21)Department: PathologyThis project is focused on understanding the molecular mechanisms of prostate tumor initiation due the loss of the tumor suppressor gene Nkx3.1. Here, we examined the dosage-sensitive and stochastic target gene regulation ...
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(2014-07-22)Department: PathologyNormal tissue repair involves a series of highly coordinated events that include inflammation, granulation tissue formation, revascularization, and tissue remodeling. The transcriptional co-factor, ankyrin repeat domain ...
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(2015-12-16)Department: PathologyImproved therapies for high grade gliomas (HGG) are urgently needed, as the median survival for grade IV gliomas is just 15 months after treatment with surgery, chemotherapy and radiation. Recently, bone morphogenetic ...
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(2011-07-26)Department: PathologyCharacterization of fibrinogen-binding surface protein B (FbsB) in human blood coagulation and fibrinolysis, and of the NH2-terminal dipeptide of staphylocoagulase (SC) in conformational prothrombin activation are presented ...
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(2014-08-15)Department: PathologyThe oncogenes Mdm2 and Mdmx are often overexpressed in many human cancers. In addition to being negative regulators of the tumor suppressor p53, there is evidence these proteins have important p53-independent functions ...
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(2018-04-12)Department: PathologyThe endometrium is the tissue lining the inner cavity of the uterus in which nidation and pregnancy maintenance occurs. To date, there are no physiological models that recapitulate the human endometrial microenvironment; ...
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(2016-12-05)Department: PathologyExtracellular matrix (ECM) functions as the insoluble scaffold of tissues that controls cellular behaviors and regulates environmental cues that are essential for many aspects of biology. Basement membranes (BMs) are ...
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(2007-09-20)Department: PathologyThis project is concerned with the lysosomal accumulation of lipid in the developing macrophage foam cell as occurs in the atherosclerotic lesion. Lysosomal lipid accumulation in atherosclerosis is a feature of advanced ...
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(2011-05-03)Department: PathologyInvariant natural killer T (iNKT) cells are a specialized subset of immune regulatory cells that recognize glycolipid antigens and are thought to be pro-atherogenic under hyperlipidemic conditions. We previously reported ...
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(2009-04-08)Department: PathologyPATHOLOGY LOCAL SIGNALING MICRODOMAINS IN EXCITABLE CELLS: DEFINING NOVEL ROLES FOR ANKYRIN-B IN ION CHANNEL TARGETING AND REGULATION CRYSTAL FAITH KLINE Dissertation under the direction of Professor Peter J. Mohler The ...
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(2013-07-29)Department: PathologyCystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Alterations in polyunsaturated fatty acid (PUFA) levels have been consistently described ...
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(2013-07-31)Department: PathologyThe high prevalence of prostate cancer makes it an attractive target for a widespread prevention measure. Oxidative stress has been implicated in prostate cancer, but the roles it plays throughout the stages of tumorigenesis ...
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(2011-04-04)Department: PathologyBone marrow-derived mesenchymal stem cells (MSCs) are an attractive candidate for cell-mediated wound repair. Due to their plasticity, MSCs have been utilized in several preclinical and clinical trials of tissue regeneration. ...
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(2009-09-11)Department: PathologyProstate cancer is the most commonly diagnosed cancer in American men. Although much progress has been made in identifying the genetic alterations that underlie this disease, there remains a gap in our understanding of how ...
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(2010-01-04)Department: PathologyThe studies in this dissertation defined the molecular mechanism of prothrombin (ProT) activation by a recently-identified Staphylococcus aureus exoprotein, von Willebrand factor-binding protein (VWbp). We demonstrated ...
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(2013-07-31)Department: PathologyTNF-α, produced by most malignant cells, orchestrates the interplay between malignant cells and myeloid cells, which have been linked to tumor growth and metastasis. Although TNF-α can exist as one of two isoforms, a ...
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(2015-03-18)Department: PathologyAtherosclerosis is the driving force behind cardiovascular disease, the principal cause of death in the world today. To complement currently available interventions, such as statins which reduce risk of a major cardiac ...
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(2019-10-29)Department: PathologyHeterogeneity in estrogen receptor positive breast cancers is poorly understood. Copy number alterations and structural differences contribute to carcinogenesis. Current cell line genomes representing the histological ...