Browsing by Department "Neuroscience"
Now showing items 1-20 of 220
-
(2021-04-02)Department: NeuroscienceManganese (Mn) is a biologically essential metal, critical as a cofactor for numerous enzymes such a glutamine synthetase and kinases such as ataxia-telangiectasia mutated (ATM). Similar to other essential metals, such as ...
-
(2023-03-08)Department: NeuroscienceLearning to read is an important milestone in children’s development. Factors in the home environment is been linked to the behavioral and neural correlates of reading, but further work is needed to unpack the underlying ...
-
(2014-09-29)Department: NeuroscienceThe essential micronutrient manganese is enriched in brain, especially the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, as previous data suggested ...
-
(2010-04-10)Department: NeuroscienceABSTRACT Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder predominantly afflicting the striatum. It is clear that an expansion of a glutamine encoding CAG triplet-repeat in the Huntingtin ...
-
(2014-04-17)Department: NeuroscienceBoth dopamine and glutamate are critically involved in cognitive processes such as working memory. Evidence has demonstrated that manipulation of either neurotransmitter can lead to alterations in the other. Astrocytes, ...
-
(2014-08-28)Department: NeuroscienceThe p75 Neurotrophin Receptor (p75NTR) is a critical regulator of axon pruning and apoptosis during neurodevelopment. Because the receptor has also been associated with many injurious or pathological conditions involving ...
-
(2018-03-29)Department: NeuroscienceThe prefrontal cortex (PFC) is most commonly defined as the frontal cortical area receiving a mediodorsal (MD) thalamic innervation, however other have put forth that the PFC in the zone of convergent innervation from the ...
-
(2022-03-25)Department: NeuroscienceGlaucoma results from progressive degeneration and eventual death of retinal ganglion cells (RGCs) and is the leading cause of irreversible blindness worldwide. Neuroprotective agents are needed to protect RGCs because the ...
-
(2021-02-10)Department: NeuroscienceCritical periods are developmental windows during which neural circuits restructure to the new sensory environment. The Drosophila antennal lobe (AL) provides a genetically-tractable model system to study the cellular and ...
-
(2012-12-07)Department: NeuroscienceThe proper function of the nervous system is dependent upon a delicate balance between excitatory and inhibitory activity in the brain. GABAA receptors are extremely important in the maintenance of this balance because ...
-
(2009-01-20)Department: NeuroscienceRNA transcripts encoding the 2C-subtype of the serotonin (5HT2C) receptor are modified by adenosine-to-inosine editing events to generate as many as twenty-four 5HT2C receptor protein isoforms. These modified receptors are ...
-
(2008-03-31)Department: NeuroscienceThe primate visual system is highly interconnected and hierarchically organized. Three separate pathways, originating in the layers of the lateral geniculate nucleus (LGN), carry retinal information to primary visual cortex ...
-
(2022-03-23)Department: NeuroscienceThe vertebrate head is a complex structure consisting of diverse tissues that work cooperatively to perform a variety of craniofacial functions, such as speaking, breathing, processing and swallowing food, among others. ...
-
(2017-09-26)Department: NeuroscienceSubclinical ascorbate deficiency is widespread in many populations, but its role in both Alzheimer’s disease and normal aging is understudied. We decreased brain ascorbate in the APPSWE/PSEN1deltaE9 mouse model of Alzheimer’s ...
-
(2019-06-13)Department: NeuroscienceGlaucomatous Optic Neuropathy (glaucoma) challenges retinal ganglion cell axons through sensitivity to intraocular pressure (IOP). Axons rely upon astrocyte energy stores (glycogen) to combat neurodegenerative stress. We ...
-
(2018-04-18)Department: NeuroscienceA significant body of research has indicated that acuity of the neurocognitive system used to represent numerical magnitudes, often referred to as the approximate number system (ANS), serves a foundational role in the ...
-
(2018-12-03)Department: NeuroscienceIt is now a well-established finding that the human brain has a ``small-world' architecture, which is characterized by densely connected modules and a highly-connected hub network. It has been hypothesized that this ...
-
(2019-09-16)Department: NeuroscienceCochlear implants (CIs)-widely considered the most successful neuroprosthetic devices-afford over half a million users worldwide access to sound perception following severe-to-profound hearing loss. However, visual cues ...
-
(2015-12-08)Department: NeuroscienceAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social behavior. It is unclear if deficits are due to disinterest in social stimuli, or to an elevated stress response. The ...
-
(2015-11-19)Department: NeuroscienceDue to the escalating obesity epidemic in the United States, an important public health concern is the comorbidity of metabolic disorders and mental illness. Mounting clinical evidence supports the comorbid nature of mental ...