Browsing by Department "Microbe-Host Interactions"
Now showing items 1-20 of 36
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(2020-04-03)Department: Microbe-Host InteractionsMosquito inoculation of humans with arthritogenic alphaviruses results in a febrile syndrome characterized by debilitating musculoskeletal pain and arthritis. Despite an expanding global disease burden, no approved therapies ...
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(2021-05-17)Department: Microbe-Host InteractionsInfection remains a common and deadly risk for vulnerable patients due to rising antibiotic resistance, aging populations, and increasingly complex medical care. Prophylactic immunomodulation that bolsters host immunity ...
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Characterization of functional human antibodies targeting henipavirus and flavivirus glycoproteins (2021-06-14)Department: Microbe-Host InteractionsThe henipaviruses Hendra (HeV) and Nipah (NiV), and the flavivirus yellow fever (YFV), pose massive global public health threats. No small molecule or antibody-based countermeasures are available to treat humans infected ...
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(2022-07-20)Department: Microbe-Host InteractionsHantaviruses are high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact. While sporadic in North and South America, many infections ...
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(2022-11-18)Department: Microbe-Host InteractionsViruses with multi-segmented genomes are unique in their capacity to readily exchange large amounts of genetic information via a process known as reassortment. Reassortment requires a considerable amount of genetic ...
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(2022-01-04)Department: Microbe-Host InteractionsCoronaviruses (CoVs) are a genetically diverse group of positive-sense single-stranded RNA viruses containing the largest known genome of any RNA virus, >30 kb, and responsible for the current COVID-19 pandemic (SARS-CoV-2). ...
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(2022-03-15)Department: Microbe-Host InteractionsUropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and among the most successful human bacterial pathogens worldwide. Despite being a facultative anaerobe, UPEC requires aerobic respiration ...
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(2022-06-10)Department: Microbe-Host InteractionsGroup B Streptococcus (GBS), or Streptococcus agalactiae, is one of the leading causes of infection-related adverse pregnancy and neonatal outcomes, which include stillbirth, chorioamnionitis, preterm birth, and neonatal ...
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(2022-03-24)Department: Microbe-Host InteractionsExisting viral pathogens like human immunodeficiency virus (HIV), influenza virus, and coronaviruses, along with emerging infectious diseases, are constant worldwide threats, causing illness and death for millions of people ...
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(2023-03-27)Department: Microbe-Host InteractionsDuring a field expedition with the Centers for Disease Control and Prevention to South Sudan and Uganda, a wildlife researcher who had been collecting bat and rodent samples became ill and was hospitalized with a severe ...
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(2022-05-16)Department: Microbe-Host InteractionsAntibiotic resistance is a growing global health threat. According to the CDC, nearly 2.8 million drug-resistant infections occur every year, killing 35,000 people annually. While research has focused on the acquisition ...
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(2020-02-03)Department: Microbe-Host InteractionsFunctional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPRC) has been implicated in the generation of negative affective states under stressful conditions in both humans and rodents; however, the ...
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(2022-06-14)Department: Microbe-Host InteractionsGram-negative bacteria are frequently opportunistic pathogens that cause significant morbidity and mortality in humans. Escherichia coli and Klebsiella pneumoniae are two common Gram-negative pathogens that often acquire ...
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(2023-03-27)Department: Microbe-Host InteractionsTraditional therapeutics and vaccine regimens have been responsible for saving millions of lives and eliminating some of the deadliest diseases; however, many threats remain, and new threats continue to emerge. Pathogens ...
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(2022-03-23)Department: Microbe-Host InteractionsChronic mucosal pathogens have evolved multiple strategies to manipulate the host immune response; consequently, microbes contribute to the development of >2 million cases of cancer/year. Gastric adenocarcinoma is the ...
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(2021-12-21)Department: Microbe-Host InteractionsHelicobacter pylori population dynamics in vitro and in vivo Margaret Lorena Harvey Dissertation under the direction of Dr. Timothy L. Cover The Gram-negative bacterium Helicobacter pylori colonizes the human stomach ...
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(2020-03-31)Department: Microbe-Host InteractionsHelicobacter pylori is a Gram-negative bacterium that colonizes the gastric mucosa and has the potential to cause peptic ulcer disease and gastric cancer. The risk of developing gastric cancer is determined by multiple ...
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(2022-10-27)Department: Microbe-Host InteractionsRift Valley fever virus (RVFV) and Crimean Congo Hemorrhagic fever virus (CCHFV) are two lethal viruses that impact human health. Little is known about the human antibody response to either virus. In this work, I show that ...
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(2022-06-10)Department: Microbe-Host InteractionsT cell metabolic programming is dynamic and shifts to support the energetic, biosynthetic, and signaling demands of T cell inflammatory or regulatory functions. Failure to meet these metabolic requirements can cause T cell ...
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(2022-05-16)Department: Microbe-Host InteractionsAlthough the intestinal and skeletal systems are spatially distinct organ systems, they share many overlapping features and are linked by specific cellular and molecular pathways. Works described in this dissertation ...