Browsing by Department "Microbe-Host Interactions"

Now showing items 21-29 of 29

    • Mechanisms of Lactobacillus-mediated protection against Respiratory Syncytial Virus infection and pathogenesis 
      Strickland, Britton Alexander; 0000-0003-4507-1163 (2022-11-22)
      Department: Microbe-Host Interactions
      Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in children below the age of two years. RSV acute respiratory infection during infancy strongly correlates ...
    • Neutralization mechanisms of human anti-alphavirus monoclonal antibodies 
      Williamson, Lauren; 0000-0002-2725-5826 (2021-03-10)
      Department: Microbe-Host Interactions
      MICROBE-HOST INTERACTIONS Neutralization Mechanisms of Human Anti-alphavirus Monoclonal Antibodies Lauren Elizabeth Williamson Dissertation under the direction of Professor James E. Crowe, Jr. Alphaviruses cause a ...
    • Nutrient homeostasis in Acinetobacter baumannii 
      Lonergan, Zachery Ryan; 0000-0001-7694-2166 (2020-03-03)
      Department: Microbe-Host Interactions
      Zinc is an essential nutrient metal required as a catalytic or structural cofactor for thousands of proteins. During infections, the opportunistic bacterial pathogen Acinetobacter baumannii must acquire zinc and other ...
    • The Antiviral Mechanism of SERINC5 on HIV-1 Infection 
      Featherstone, Austin Blake; 0000-0002-5039-3549 (2020-11-18)
      Department: Microbe-Host Interactions
      SERINC5 is a 10-12 transmembrane domain cellular protein that is incorporated into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV-1 susceptibility to SERINC5 is determined by ...
    • The Bacillus anthracis two-component system signaling response to host stressors. 
      Laut, Clare Lynn; 0000-0002-6281-9199 (2021-03-30)
      Department: Microbe-Host Interactions
      In bacteria, stress-induced gene expression changes can occur via signal transduction systems known as two-component systems (TCSs). Bacillus anthracis, the causative agent of anthrax, encounters numerous stressors that ...
    • The Role of Metabolism in Th2 and Th17 Cells During Airway Inflammation 
      Contreras Healey, Diana Carolina; 0000-0001-6981-8386 (2021-03-14)
      Department: Microbe-Host Interactions
      T cells play an important role in promoting inflammation in asthmatic patients and both Th2 and Th17 CD4+ T cells have been implicated in severe disease. The metabolic phenotypes and dependencies of these cells, however, ...
    • The Role of RNA Binding Proteins in Regulating Infection and Double-stranded RNA Sensing 
      Dunker, William; 0000-0002-3271-4345 (2021-07-23)
      Department: Microbe-Host Interactions
      RNA binding proteins (RBPs) interact with double or single-stranded RNA and regulate numerous stages of RNA metabolism. My thesis investigates Fused-in-sarcoma (FUS) and TAR DNA-binding protein (TDP-43), two ubiquitous ...
    • THE ROLE OF THE GRAM-NEGATIVE CELL ENVELOPE IN THE PATHOGENESIS AND TREATMENT OF PNEUMONIA 
      Wijers, Christiaan Diederik Mathijs; 0000-0002-0106-2962 (2022-05-16)
      Department: Microbe-Host Interactions
      Bacterial pneumonia is a leading cause of morbidity and mortality worldwide, and both host- and pathogen-derived factors contribute to pathogenesis. Acinetobacter baumannii is a Gram-negative pathogen that causes ...
    • Toward an Effective HIV-1 Vaccine: Multivalent Nanoparticle Immunogens and Public Antibodies 
      Murji, Amyn Aly; 0000-0002-4526-3205 (2021-07-20)
      Department: Microbe-Host Interactions
      Despite decades of research, there currently are no licensed HIV-1 vaccines. However, interrogation of antibody repertoires in HIV-1+ individuals have identified antibodies capable of neutralizing a broad variety of globally ...