Browsing by Department "Microbe-Host Interactions"
Now showing items 21-36 of 36
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(2021-11-15)Department: Microbe-Host InteractionsDespite significant advances in medical care, infectious diseases continue to be a leading cause of death worldwide. It is estimated that infectious diseases account for a quarter of reported deaths annually. The majority ...
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(2020-11-19)Department: Microbe-Host InteractionsHelicobacter pylori colonizes the stomach in about half of the world’s population. Gastric colonization with H. pylori strains containing the cag pathogenicity island (cag PAI) is a risk factor for gastric adenocarcinoma ...
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(2022-11-22)Department: Microbe-Host InteractionsRespiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in children below the age of two years. RSV acute respiratory infection during infancy strongly correlates ...
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(2023-03-23)Department: Microbe-Host InteractionsThis dissertation describes research aimed at understanding the role of two key virulence factors, TcsL and NanS, in Paeniclostridium sordellii infection (PSI). P. sordellii is a bacterium capable of causing uterine ...
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(2021-03-10)Department: Microbe-Host InteractionsMICROBE-HOST INTERACTIONS Neutralization Mechanisms of Human Anti-alphavirus Monoclonal Antibodies Lauren Elizabeth Williamson Dissertation under the direction of Professor James E. Crowe, Jr. Alphaviruses cause a ...
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(2020-03-03)Department: Microbe-Host InteractionsZinc is an essential nutrient metal required as a catalytic or structural cofactor for thousands of proteins. During infections, the opportunistic bacterial pathogen Acinetobacter baumannii must acquire zinc and other ...
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(2023-03-24)Department: Microbe-Host InteractionsClostridioides difficile is a Gram-positive, spore-forming bacterium and the leading cause of hospital-acquired diarrhea in the United States. Upon colonizing the colon of susceptible hosts, C. difficile causes disease ...
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(2023-11-15)Department: Microbe-Host InteractionsHelicobacter pylori strains containing the cag pathogenicity island (PAI) are associated with the development of gastric adenocarcinoma and peptic ulcer disease. The cag PAI encodes a secreted effector protein (CagA) and ...
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(2023-06-01)Department: Microbe-Host InteractionsDuring infection, pathogens must sense and respond to their environment to survive. In this thesis, I explore the mechanisms by which the gram-positive pathogens Bacillus anthracis and Staphylococcus aureus sense and adapt ...
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(2020-11-18)Department: Microbe-Host InteractionsSERINC5 is a 10-12 transmembrane domain cellular protein that is incorporated into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV-1 susceptibility to SERINC5 is determined by ...
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(2021-03-30)Department: Microbe-Host InteractionsIn bacteria, stress-induced gene expression changes can occur via signal transduction systems known as two-component systems (TCSs). Bacillus anthracis, the causative agent of anthrax, encounters numerous stressors that ...
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(2021-03-14)Department: Microbe-Host InteractionsT cells play an important role in promoting inflammation in asthmatic patients and both Th2 and Th17 CD4+ T cells have been implicated in severe disease. The metabolic phenotypes and dependencies of these cells, however, ...
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(2021-07-23)Department: Microbe-Host InteractionsRNA binding proteins (RBPs) interact with double or single-stranded RNA and regulate numerous stages of RNA metabolism. My thesis investigates Fused-in-sarcoma (FUS) and TAR DNA-binding protein (TDP-43), two ubiquitous ...
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(2022-05-16)Department: Microbe-Host InteractionsBacterial pneumonia is a leading cause of morbidity and mortality worldwide, and both host- and pathogen-derived factors contribute to pathogenesis. Acinetobacter baumannii is a Gram-negative pathogen that causes ...
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(2023-03-24)Department: Microbe-Host InteractionsStaphylococcus aureus is a leading cause of bacterial infections and can infect nearly every organ of the human body. One common manifestation of S. aureus disease is invasive bone infection, or osteomyelitis. Osteomyelitis ...
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(2021-07-20)Department: Microbe-Host InteractionsDespite decades of research, there currently are no licensed HIV-1 vaccines. However, interrogation of antibody repertoires in HIV-1+ individuals have identified antibodies capable of neutralizing a broad variety of globally ...