Browsing by Department "Chemistry"
Now showing items 1-20 of 340
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(2015-03-11)Department: ChemistryWe developed a novel approach for the general and enantioselective synthesis of a diverse array of small to large 1-azabicyclo[m.n.0]alkyl ring systems with an embedded olefin handle for further functionalization. The ...
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(2012-11-05)Department: ChemistryThe azabicyclic ring system is a common structural subunit present in numerous alkaloid natural products and serves as an important scaffold in biologically active and pharmaceutically significant compounds. Pyrrolizidine, ...
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(2012-03-31)Department: ChemistryJohnston and coworkers recently reported a novel amide bond forming reaction wherein the amine acts as the electrophile and the carbon donor acts as the nucleophile (Umpolung Amide Synthesis). In the following study, the ...
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(2007-04-09)Department: ChemistryThe identification of tumor margins is vital for successful patient outcome, preventing local recurrence and ensuring long-term survival. Current techniques used to assess tumor margins for successful tumor removal require ...
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(2011-12-09)Department: ChemistryThe experimental elucidation of protein structures is one of the central tasks of structural biology. The structure of a protein defines its function within a cell helping us to understand the biology of organisms. Protein ...
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(2016-08-12)Department: ChemistryComputational approaches have become important tools in drug discovery. Computational technologies have been developed for application in all aspects of the drug discovery process including target identification, lead ...
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(2014-07-26)Department: ChemistryAs part of a long-range project to develop inexpensive, earth-abundant alternatives to the use of rare-earth metals in catalysts, it was discovered that an unusual color is generated when solutions of Ca[1,3-(SiMe3)2C3H3]2(thf)2 ...
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(2017-12-06)Department: ChemistryPart A: Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Although the efficiency ...
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(2016-03-30)Department: ChemistryMatrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) allows for the high-throughput analysis of plasma samples for pharmaceutical drugs. A new multiplexing time-of-flight instrument with a continuous ...
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(2021-06-15)Department: ChemistryNatural product discovery and synthetic biology workflows use natural constructs such as bacteria for the production and discovery of chemical commodities. Natural product discovery leverages the millions of years of ...
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(2021-03-23)Department: ChemistryThe activation and transformation of relatively inert bonds through transition metal mediated reactions is central to the field of organometallic chemistry. The ability of transition metal d orbitals to engage in backbonding ...
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(2021-03-09)Department: ChemistryThe intermolecular activation and functionalization of inert sp3 bonds using transition-metal complexes has remained a challenging area of research. Cationic dihydrido bis(phosphine) iridium complexes are found to activate ...
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(2014-02-11)Department: ChemistryThe overarching goal of this research is to explore novel approaches to mass spectrometry (MS) analysis in order to address current challenges in the technique. The primary focus of this document is nanostructure-initiator ...
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(2011-08-02)Department: ChemistryIon mobility-mass spectrometry (IM-MS) provides rapid (μs-ms) two dimensional separations on the basis of molecular structure and mass-to-charge (m/z), respectively. Based on differences in intramolecular packing of various ...
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(2013-03-04)Department: ChemistryThis work explores the application of mass spectrometry-based multidimensional separations to metabolite analysis. The advent of a gas phase structure-based prioritization method for secondary metabolite prioritization and ...
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(2021-07-14)Department: ChemistryDirect functionalization of unactivated C-H bonds presents a longstanding challenge in the field of synthetic chemistry, largely addressed by the use of low-valent transition metal catalysts and development of corresponding ...
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(2014-07-28)Department: ChemistryQuantitative structure activity relationship (QSAR) modeling using high-throughput screening (HTS) data enables the development of predictive models for in silico screening. A cheminformatics framework termed BCL::ChemInfo ...
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(2013-04-16)Department: ChemistryAflatoxin B1 (AFB1), a carcinogenic mycotoxin produced by the common agricultural contaminant A. flavus, has been implicated in the high rates of hepatocellular carcinoma observed in some developing countries. Upon ...
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(2007-12-27)Department: ChemistryThree constructs of African Swine Fever Virus DNA polymerase X (pol X) were expressed and purified. Buffers containing sodium acetate, sodium cacodylate or 0.5 M NaCl provided good solubility for the enzyme at micromolar ...
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(2021-03-25)Department: ChemistryThe development of novel analytical methods and instrumentation has enabled the characterization of increasingly complex samples. In particular, mass spectrometry (MS) is a technique that has found broad application in the ...