Browsing by Department "Chemistry"
Now showing items 21-40 of 346
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(2007-12-27)Department: ChemistryThree constructs of African Swine Fever Virus DNA polymerase X (pol X) were expressed and purified. Buffers containing sodium acetate, sodium cacodylate or 0.5 M NaCl provided good solubility for the enzyme at micromolar ...
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(2023-11-16)Department: ChemistryThe cancer treatment regimen known as AC chemotherapy is one of the oldest and most commonly used regimens. Consisting of a combination of Adriamycin (Doxorubicin) and Cyclophosphamide, it has long been understood that the ...
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(2021-03-25)Department: ChemistryThe development of novel analytical methods and instrumentation has enabled the characterization of increasingly complex samples. In particular, mass spectrometry (MS) is a technique that has found broad application in the ...
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(2011-07-11)Department: ChemistryNew highly sensitive strategies for the analysis of proteins from selected cell populations in morphologically complex tissues have been developed. These workflows combine the single cell specificity of laser capture ...
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(2022-11-16)Department: ChemistryOne of the most commonly used chemotherapeutic regimens is the adjuvant combination therapy called Adriamycin/Cyclophosphamide (AC) Chemotherapy. These two drugs are understood to work separately to induce an additive ...
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(2014-06-26)Department: ChemistryMy doctoral research has focused on (i) using organocatalysis to prepare enantioenriched pharmaceutically relevant scaffolds and (ii) preparing isoenzyme selective inhibitors of phospholipase D. (i) Methodologies for ...
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(2013-08-01)Department: ChemistryAziridines represent an important class of nitrogen-containing heterocycles with a wide range of synthetic utility. Despite their value, synthetic approaches are limited in terms of generality and diversity. On this ...
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(2011-07-15)Department: ChemistryIn the field of organocatalysis, the use of small organic molecules has had a significant impact on chemical synthesis, providing a mild and practical alternative to the more conventional metal based catalyst. The selective ...
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(2016-03-07)Department: ChemistryApplications of Chiral Amidine Catalysis Towards the Synthesis of Small Molecule Therapeutics and Recent Advances in Vicinal Diamine Synthesis Michael W. Danneman Dissertation Under the Direction of Professor Jeffrey N. ...
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(2015-06-05)Department: ChemistryHemiketal D2 and hemiketal E2 are eicosanoids identified by Schneider and coworkers in 2011. These novel arachidonic acid metabolites are cross-over products of the enzymes 5-LOX and COX-2, previously assumed to be operating ...
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(2009-12-10)Department: ChemistryInitial studies on the development of diagnostic applications for backscattering interferometry (BSI) are presented. Backscattering interferometry (BSI) is a label-free technique developed by the Bornhop laboratory which ...
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(2007-04-14)Department: ChemistryThe movement of molecular analyses to u-TAS formats has grown exponentially over the past decade. This in turn has led to the development of new and innovative detection schemes to perform analyses on micro- and nanoarrays. ...
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(2010-06-01)Department: ChemistryAs the field of chemical biology evolves, so does the development of novel bioanalytical techniques capable of accurately measuring biochemical composition and regulation. This dissertation explores three aspects of ...
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(2014-03-21)Department: ChemistryOver the course of billions of years, nature has developed incredible materials on the nanoscale for the efficient conversion of solar energy into chemical energy. One of these materials, Photosystem I (PSI), functions as ...
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(2009-08-11)Department: ChemistryThe use of fluorescent microscopy as a tool for studying biological systems has exploded with the development of the laser scanning confocal microscope. In conjunction with traditional biochemical techniques, it can plan ...
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(2006-12-13)Department: ChemistryCurrent approaches to the synthesis of metal oxides generally require harsh conditions. In contrast, many biological processes can produce intricate metal oxide nanostructures under ambient conditions. For example, the ...
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(2014-04-01)Department: ChemistryIon mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
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Biosynthetic Derivatization of Antimicrobial Orthosomycins to Engage a Unique Ribosomal Binding Site (2021-02-19)Department: ChemistryAntimicrobial resistance is a critical threat to human health that results in an estimated 100,000 deaths in the United States each year, according to the World Health Organization. This growing crisis demands the development ...
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(2011-02-17)Department: ChemistryThe dissertation contained herein describes biosynthetic investigations of the peptide natural products K-26 and anthramycin. Unified by their peptidic nature, K 26 and anthramycin are potent biologically active metabolites ...
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(2008-06-24)Department: ChemistryMass spectrometry is a powerful technique that can be used at every stage of natural product studies, from discovery and structural characterization of new compounds to biosynthetic enzyme identification and manipulation. ...