Browsing by Department "Chemical Engineering"
Now showing items 1-20 of 131
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(2018-11-26)Department: Chemical EngineeringChinese hamster ovary (CHO) cells are the most commonly utilized host cell line for biomanufacturing monoclonal antibody (mAb) drugs and other therapeutic proteins. This dissertation describes the application of 13C metabolic ...
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(2014-11-25)Department: Chemical EngineeringWe have applied 13C metabolic flux analysis (13C MFA) to develop a system-wide understanding of the central carbon metabolism of Chinese hamster ovary (CHO) cells, the most widely used host for industrial production of ...
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(2005-06-17)Department: Chemical EngineeringThis dissertation presents an original theoretical model that lumps the multiple secondary organic aerosol (SOA) components in an organic aerosol mixture into a few lumped compounds, accounting for both temperature and ...
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(2009-12-09)Department: Chemical EngineeringThis thesis details the development and testing of coarse-grained models for the key lipids found in the outmost layer of human skin, the straum corneum. Specifically, the development and optimization of coarse-grained ...
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A Piezoelectric Ink Jet Printing Platform to Engineer Microparticles for Drug Delivery Applications (2018-07-18)Department: Chemical EngineeringMicroparticles are widely researched for use as drug delivery vehicles for numerous applications due to their ability to eliminate side effects and decrease dose frequency. However, there lacks a comprehensive technology ...
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(2007-02-16)Department: Chemical EngineeringCHEMICAL ENGINEERING A STATISTICAL ASSOCIATING FLUID THEORY FOR POLAR AND ELECTROLYTE FLUIDS HONGGANG ZHAO Dissertation under the direction of Professor Clare McCabe The ability to accurately predict the thermodynamic ...
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(2021-03-18)Department: Chemical EngineeringDespite the potency of most first-line anti-cancer drugs, non-adherence to these drug regimens remains high and is attributable to the prevalence of “off-target” drug effects that result in serious, adverse events (SAEs) ...
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(2016-03-30)Department: Chemical EngineeringAdsorption is an interfacial phenomenon in which intermolecular forces between a molecule and a surface create an adsorbed phase with different properties than the bulk fluid. Variation in the adsorbed phase among different ...
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(2011-04-13)Department: Chemical EngineeringThe purpose of the first part of this dissertation is to study the potential use of metal-organic frameworks (MOFs) as novel adsorbents to capture carbon dioxide from flue gases mainly generated by coal-fired power plants. ...
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(2014-04-01)Department: Chemical EngineeringThe ability to accurately predict mixture adsorption equilibrium is vital for future gas separation technologies. This research concentrates on the investigation and prediction of adsorption equilibrium of pure components ...
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(2010-12-16)Department: Chemical EngineeringHealing of bone defects such as open fractures is a challenging clinical problem. An ideal treatment for bone defects would restore both form and function of the tissue. In this research, a two-component allograft bone ...
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(2019-03-25)Department: Chemical EngineeringMetastasis is the major prognostic factor for cancer patient survival, and breast tumors have a striking propensity for metastasis to bone. Once tumors establish in bone, they initiate what is colloquially known as the ...
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(2005-06-07)Department: Chemical EngineeringTime-of-flight medium backscattering (TOF-MEBS) is a powerful analytical technique for characterizing high-k dielectric thin films and their interface with Si. The amount of information that can be obtained from backscattering ...
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(2004-04-09)Department: Chemical EngineeringMethylglyoxal (MG) is a toxic compound which is produced in cells as a byproduct of glycolysis. Recently, the compound has been suggested as a damaging agent in batch cultures of production cell lines. In the current ...
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(2022-05-04)Department: Chemical EngineeringMonoclonal antibodies (mAbs) represent the largest class of biopharmaceuticals, accounting for over 50% of new drug approvals and 65% of global biopharmaceutical sales. Due to their complexity, mAbs are typically produced ...
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(2010-05-21)Department: Chemical EngineeringInfection is a common complication in open fractures that compromises bone healing. Currently, the clinical standard care for treating contaminated open fractures comprises a staged approach, wherein the wound is first ...
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(2018-03-26)Department: Chemical EngineeringT-lymphocytes use their surface T-cell receptors (αβTCRs) to recognize sparse antigenic peptides bound to MHC molecules (pMHC) arrayed on antigen presenting cells (APCs). Both T-cell movements and cytoskeletal rearrangements ...
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(2013-03-25)Department: Chemical EngineeringIn this work, molecular simulations are used to calculate the vapor-liquid equilibrium (VLE) of polymer-grafted nanoparticles under a wide range of conditions, with the main goal to explore the balance between nanoparticle-polymer ...
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(2019-07-19)Department: Chemical EngineeringPolyurethanes (PURs) are an attractive material for tissue engineering bone graft substitutes since they can be formulated to be injectable, settable, and biocompatible, and their mechanical properties and degradation rates ...
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(2014-03-31)Department: Chemical EngineeringProduction of high-purity oxygen from air by pressure-swing adsorption (PSA) is of interest for a variety of applications. One recognized area for which this technology could be particularly useful is the development of ...