Lung cancer remains the leading cause of all cancer-associated mortalities within the United States. A contributing factor to the high mortality rate is heterogeneous patient response to cancer treatment. This work ...

The type II topoisomerases are the targets of both anticancer and antibacterial therapies. These enzymes perform critical actions in the cell, including unwinding, unknotting, and untangling the genome, through the ...

Mathematical models are becoming increasingly used to describe biochemical processes and understand the systems behavior that arises from protein-protein interactions involved in a biochemical pathway. These complex ...

Patients who have undergone radiation therapy for brain metastases often have latent lesions such as recurrent tumor or radiation necrosis. Differentiating these lesions in vivo is critical for providing adequate care, but ...

My graduate work has primarily focused on using computational methods applied to early-stage drug discovery. This has involved method development projects that aim to improve existing computational methods, while also ...

Cholesterol is one of the major lipid components of the plasma membrane in all mammalian cells. It has been shown to modulate membrane fluidity, assembly, organization, and dynamics and alter integral membrane protein (IMP) ...

Pathogen-specific human B cells represent a rich source of antibodies that have been selected for by the process of affinity maturation. In the last few decades, a number of approaches have been developed for the identification ...

In the past two decades, monoclonal antibodies have established their role as effective therapeutic agents for several disease types. This has amplified the interest of using them as diagnostic and therapeutic tools in ...

Secondary active transporters are integral membrane proteins that harness the potential energy stored in electrochemical ion gradients to import and export substrates across cell membranes. Transporters with the LeuT-fold ...

Faithful duplication of DNA lies at the center of DNA replication, defects in which can lead to cancer and other diseases of genomic instability. Generating copies of the two stands of the DNA duplex begins with synthesis ...