Browsing by Department "Chemical & Physical Biology"
Now showing items 21-39 of 39
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(2020-07-13)Department: Chemical & Physical BiologyPredicting how cells respond to drugs is a core concept in systems biology modeling. Current available methods for these signaling analyses can be broadly be classified into two categories: local “bottoms-up” and global ...
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(2023-03-14)Department: Chemical & Physical BiologySystems biology leverages high-dimensional molecular data at single-cell and spatial resolution to elucidate and characterize emergent phenomena in human health and disease. Through data-driven modeling and integration, ...
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(2020-06-12)Department: Chemical & Physical BiologyThe overall goal of this dissertation is to develop and evaluate magnetic resonance imaging (MRI) methods to characterize peripheral nerve microstructure and pathologies in vivo in humans. More specifically, we assessed ...
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(2022-03-24)Department: Chemical & Physical BiologyDissertation under the direction of Dr. Vito Quaranta Epigenetic heterogeneity underlies acquired resistance to therapy in several cancer types. Small cell lung cancer (SCLC) is a particularly recalcitrant form of lung ...
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(2022-06-28)Department: Chemical & Physical BiologyStroke is caused by stenosis, occlusion, or rupture of a blood vessel supplying the brain, and is a leading cause of adult disability and death in the United States. However, due to advancements in therapies to prevent ...
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(2021-05-12)Department: Chemical & Physical BiologyTranscranial focused ultrasound (FUS) is being studied for a number of research and clinical applications in the brain. Transcranial FUS is able to generate bioeffects with minimal invasiveness on a millimeter-scale. It ...
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(2020-04-01)Department: Chemical & Physical BiologyMultiple cellular processes, including cell growth, the cell cycle, metabolism, differentiation, transformation, and apoptosis are regulated by MYC proteins. The frequent deregulation of MYC and its elevated expression via ...
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Structural and Biophysical Investigation of Calmodulin Binding to the Third Domain of Human Prp40A (2022-06-15)Department: Chemical & Physical BiologyHuman Pre-mRNA-processing factor 40 homolog A (hPrp40A) is a splicing factor that interacts with the Huntington’s Disease (HD) protein huntingtin (HTT). Evidence has accumulated that both HTT and hPrp40A are modulated by ...
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(2020-04-03)Department: Chemical & Physical BiologyThe multidrug and toxic compound extrusion (MATE) transporters are a ubiquitous family of efflux pumps that couples efflux of structurally and chemically diverse molecules to an inwardly-directed Na+ or H+ electrochemical ...
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(2021-05-17)Department: Chemical & Physical BiologyCancer is a disease in need of selectively cytotoxic agents – ‘magic bullets’ which target cancerous cells while sparing healthy cells. Microbial secondary metabolites represent a rich source of clinically useful compounds ...
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(2022-11-15)Department: Chemical & Physical BiologyATPases Associated with diverse cellular Activities (AAA+) proteases power the maintenance of protein homeostasis by coupling ATP hydrolysis to mechanical protein unfolding, translocation, and ultimately degradation. Though ...
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(2022-11-15)Department: Chemical & Physical BiologyATPases Associated with diverse cellular Activities (AAA+) proteases power the maintenance of protein homeostasis by coupling ATP hydrolysis to mechanical protein unfolding, translocation, and ultimately degradation. Though ...
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(2023-03-14)Department: Chemical & Physical BiologyN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) is a zinc metallohydrolase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to form N-acyl-ethanolamides (NAEs) and phosphatidic acid. Several ...
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(2020-10-28)Department: Chemical & Physical BiologyExposure of cells to diverse types of stressful environments differentially regulates cell fate. Although many types of stresses causing this differential regulation are known, it is unknown how changes over time of the ...
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(2022-01-20)Department: Chemical & Physical BiologyThe kidney proximal tubule is the primary site for solute reabsorption, secretion and where kidney diseases can originate, including drug-induced toxicity. Two-dimensional cell culture systems of the human proximal tubule ...
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(2022-02-11)Department: Chemical & Physical BiologyComplex systems contain several hierarchical levels of abstracted information and function, which attenuate the effectiveness of traditional analytical methods. The application of systems theory and machine learning for ...
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(2020-03-20)Department: Chemical & Physical BiologyThe hormone erythropoietin (Epo) is required for erythropoiesis, yet its molecular mechanism of action remains poorly understood. To investigate how Epo modulates the erythroid genome, I performed epigenetic profiling using ...
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Using Protein Flexibility to Model Viral Glycoprotein Mutation Tolerances and Sites of Vulnerability (2020-06-16)Department: Chemical & Physical BiologyBioinformatic and epitope mapping approaches have been successful, but are reactive, in determining the mutation preferences and commonly targeted B-cell epitopes of viral fusion proteins. The primary motivation of this ...
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(2021-06-08)Department: Chemical & Physical BiologySignal transduction is the process by which an external signal is transmitted into a cell to induce a cellular response. Cells have evolved robust mechanisms to interpret and respond to these external signals as they modify ...