Browsing by Department "Cell and Developmental Biology"
Now showing items 1-20 of 179
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(2010-07-15)Department: Cell and Developmental BiologyWnt/β‐catenin signaling plays a critical role in metazoan development, stem cell maintenance, and human disease. The multicomponent β‐catenin destruction complex maintains low cellular β‐catenin in the absence of a signal ...
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(2014-11-26)Department: Cell and Developmental BiologyMitotic kinesins represent the new age targets of spindle-poisoning chemotherapies. The kinesin-5 Eg5 is one such example, as kinesin-5 inhibitors (K5Is) induce a lethal mitotic arrest from failed spindle assembly. ...
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(2014-06-20)Department: Cell and Developmental BiologyMicrotubule plus-end tracking proteins (+TIPs) are a specialized group of microtubule-associated proteins (MAPs) that preferentially localize to microtubule (MT) plus-ends. This unique localization is thought to be due to ...
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(2011-08-16)Department: Cell and Developmental BiologyEvaluation of late events in cardiovascular development is precluded mid-gestational embryonic lethality associated with most traditional endothelial specific gene knockouts. Thus, it has not been possible to study late ...
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(2011-12-10)Department: Cell and Developmental BiologyInformation flow in nervous systems depends on the asymmetric organization of neurons; neurotransmitters are released from presynaptic domains and stimulate receptors localized to postsynaptic regions. These specialized ...
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(2017-03-30)Department: Cell and Developmental BiologyThe final steps of cell division are tightly coordinated in space and time but whether mechanisms exist to couple the actin and microtubule cytoskeletons during anaphase and cytokinesis (C phase) is largely unknown. We ...
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(2017-01-23)Department: Cell and Developmental BiologyMechanisms driving persistent airway inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) deficiency in small airways has been reported in COPD ...
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(2015-12-10)Department: Cell and Developmental BiologyDiabetic Retinopathy (DR) is a leading cause of blindness worldwide, and its prevalence is growing. Current therapies for DR address only the later stages of the disease, are invasive and are of limited effectiveness. ...
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(2007-04-11)Department: Cell and Developmental BiologyThe work contained in this document describes the generation of new immunoreagents for Bves study, and our identification of a Bves-interacting protein. After generating new monoclonal antibodies to the Bves protein, I ...
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(2015-11-27)Department: Cell and Developmental BiologyCargo trafficking is the process by which proteins and lipid carriers are transported between intracellular compartments. Mutations in components of cargo trafficking machinery have been associated with a diverse collection ...
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(2007-04-12)Department: Cell and Developmental BiologyIn eukaryotes, all nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs). These giant proteinaceous structures are embedded in the nuclear envelope where the outer nuclear membrane and inner nuclear ...
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(2012-08-06)Department: Cell and Developmental BiologyMesothelium is a simple squamous epithelium that forms the surface layer of all coelomic cavities and organs. Despite its widespread localization, mesothelial development has been studied almost exclusively in the heart. ...
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(2010-12-04)Department: Cell and Developmental BiologyThis project is concerned with understanding the role of the mRNA-binding protein Nab2 in the process of nuclear mRNA export. In this dissertation I characterize changes that occur to Nab2’s structure and localization ...
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(2007-07-31)Department: Cell and Developmental BiologyThe spindle pole body, the yeast analog of the centrosome, serves not only to nucleate and organize microtubules but also as a signaling center to coordinate events in mitosis and cytokinesis. It does so by localizing ...
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(2019-03-22)Department: Cell and Developmental BiologyThe basement membrane is a sheet-like extracellular matrix that wraps around muscle fibers and underlies epithelia. Although the basement membrane is often considered to be static, there are indications that the BM is a ...
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(2019-03-27)Department: Cell and Developmental BiologyThe Bcl-2 family protein Bid was originally characterized as a cytochrome c releasing factor during intrinsic apoptotic death. We and others noted that Bid is localized to the mitochondria in the absence of cell death. ...
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(2015-10-06)Department: Cell and Developmental BiologyProteins of the Bcl-2 family mediate apoptosis by altering mitochondrial structure, function, and integrity. However, in certain contexts, some members of the Bcl-2 family have additional, non-apoptotic functions. Bid, a ...
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(2010-04-12)Department: Cell and Developmental BiologyColorectal cancer is the second most lethal, non-cutaneous epithelial cancer in the United States. Metastasis contributes to the majority of cancer-related deaths in this disease. Metastasis closely resembles the ...
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(2010-04-22)Department: Cell and Developmental BiologyBone morphogenetic protein (Bmp) signaling is critical for vascular development and homeostasis. Defects in this pathway lead to multiple vascular diseases, including Heritable Pulmonary Arterial Hypertension (HPAH), which ...
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(2007-02-28)Department: Cell and Developmental BiologyThe trachea and esophagus are respectively respiratory and digestive organs that originate from a common foregut endoderm during development. Perturbed patterning in this endodermal tissue can result in a variety of foregut ...