Browsing by Department "Cell and Developmental Biology"
Now showing items 21-40 of 179
-
(2014-02-11)Department: Cell and Developmental BiologyMore than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). Two recent studies have grouped patients with BMPR2 ...
-
(2013-07-29)Department: Cell and Developmental BiologyCell division requires proper coordination of chromosome segregation and cytokinesis. Mitotic checkpoints enforce proper coordination of these two events by stalling the core cell cycle machinery when unforeseen mistakes ...
-
(2004-03-29)Department: Cell and Developmental BiologyI will introduce two novel genes isolated by my laboratory, hole and bves. This document will show that the benefits of gene discovery are invaluable. Bves, a novel family of cell adhesion molecules have been identified ...
-
(2015-12-04)Department: Cell and Developmental BiologyMyocardial infarction (MI) causes irreversible tissue damage, leading to heart failure. Our laboratory found canonical Wnt signaling and the Wnt10b ligand are strongly induced in mouse and human hearts after MI. Wnt10b ...
-
(2011-12-10)Department: Cell and Developmental BiologyDiabetes mellitus affects approximately 150 million people worldwide. This disease is characterized by hyperglycemia resulting from dysfunctional pancreatic beta cells. Current treatments for diabetics are inadequate because ...
-
(2019-05-15)Department: Cell and Developmental Biology<em>Helicobacter pylori</em> is a Gram-negative bacterium that colonizes the human stomach. More than 50% of the global population is chronically infected with <em>H. pylori</em>, and infection with <em>H. pylori</em> is ...
-
(2005-11-01)Department: Cell and Developmental BiologyThe work contained in this document provides the first description and characterization of Bves, a gene product identified by our laboratory, in epithelial cell types. Studies addressed a central hypothesis that Bves plays ...
-
(2005-07-12)Department: Cell and Developmental BiologyThe study of cytokinesis in fission yeast S.pombe has revealed a signaling network, the septation initiation network (SIN) that serves to coordinate cytokinesis with mitotic exit in the fission yeast Schizosaccharomyces ...
-
(2018-08-28)Department: Cell and Developmental BiologyCell division cycle 14 (Cdc14) is an evolutionarily conserved phosphatase originally identified in <em>Saccharomyces cerevisiae</em> as a cell cycle regulator. In <em>Drosophila melanogaster</em>, Cdc14 is encoded by a ...
-
(2005-03-25)Department: Cell and Developmental BiologyLIS1 and NudE(L) are partner proteins in a conserved pathway regulating the function of dynein and microtubules. Members of the LIS1 pathway play a critical role in fundamental cellular processes, such as differentiation, ...
-
(2015-03-27)Department: Cell and Developmental BiologyThe intestinal epithelium is a continuously renewing tissue. This rapid renewal is fueled by stem cells that reside in the base of the crypts of Lieberkühn, the functional unit of the intestinal epithelium. The identity ...
-
(2005-04-06)Department: Cell and Developmental BiologyHypoxia inducible vascular endothelial growth factor (VEGF) plays a major role in initiation and regulation of retinal neovascularization, which is the leading cause of severe vision loss and irreversible blindness in ...
-
(2014-07-28)Department: Cell and Developmental BiologyThe apical recycling endosome supported by myosin Vb (MYO5B) acts as the main decision point for both the biosynthetic and endocytic pathways as they traffic proteins to and from the apical surface in polarized cells. ...
-
(2013-07-29)Department: Cell and Developmental BiologyChronic Helicobacter pylori infection in humans causes prominent inflammation and oxyntic atrophy, which leads to two distinct types of metaplasia: intestinal metaplasia and spasmolytic polypeptide expressing metaplasia ...
-
(2017-02-28)Department: Cell and Developmental BiologySmall molecules have value in their ability to modulate protein activity in ways that are not accessible using conventional genetic methods, and their potential to be developed into therapeutics. As genetic causes of human ...
-
(2018-11-19)Department: Cell and Developmental BiologyForce generation at the cellular level is critical for eukaryotic development, homeostasis, and the progression of force dependent diseases such as cancer. Molecular motors coordinate with cytoskeletal elements, such as ...
-
(2006-04-28)Department: Cell and Developmental BiologyProstaglandin G/H synthases (PGHS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze a key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into ...
-
(2015-02-04)Department: Cell and Developmental BiologyTranscript export from the nucleus to the cytoplasm through the nuclear pore complex (NPC) is an essential step for gene expression in eukaryotes. Messenger RNAs coated in proteins (mRNPs) are able to cross the NPC due ...
-
(2010-08-05)Department: Cell and Developmental BiologyMutations in human microcephalin (MCPH1) result in a form of autosomal recessive primary microcephaly, a disorder of fetal brain growth characterized by a severely reduced cerebral cortex and head size with mental retardation. ...
-
(2017-09-14)Department: Cell and Developmental BiologyIn normal epithelial wound repair, cells across an epithelial sheet begin a coordinated process of re-epithelialization within minutes of wounding. These coordinated behaviors are driven by a calcium wave, a rise in ...