Browsing by Department "Cancer Biology"
Now showing items 1-20 of 154
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(2015-04-05)Department: Cancer BiologyE-cadherin is widely recognized as a tumor- and/or metastasis suppressor, with its activity as a cell-cell adhesion receptor is dependent on tightly coupled interactions with cytoplasmic cofactors p120-, α-, and β-catenins. ...
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(2016-07-26)Department: Cancer BiologyExosomes are extracellular vesicles that carry a variety of RNA and protein cargos, including growth factors, transmembrane proteins, angiogenic factors, proteinases, and microRNA. However, the mechanisms that regulate ...
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(2013-06-28)Department: Cancer BiologyStromal-epithelial interactions are important in both prostate development and cancer. Stromal changes have been shown to be powerful prognostic indicators of prostate cancer progression and of patient death helping to ...
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(2016-06-27)Department: Cancer BiologyγKetoaldehydes are generated by free radical peroxidation and cyclooxygenation of phospholipid-esterified arachidonic acid. γKetoaldehydes covalently bind to protein lysine residues and is emerging as a mechanistic link ...
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(2014-09-11)Department: Cancer BiologyLung cancer is the leading cause of cancer-related death in the United States and worldwide. Lung cancers that are driven by mutations in the Epidermal Growth Factor Receptor (EGFR) are treated with targeted anti-EGFR ...
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(2008-04-28)Department: Cancer BiologyWe have identified a novel signaling pathway, AKT/IKKα/VAV1, which induces endothelial cell survival and motility. Ang1/Tie2 and VEGF/VEGFR signaling activates Akt and induces cell survival. Akt and IKKƒÑ both induce ...
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(2018-03-27)Department: Cancer BiologyMetastasis persists as a significant unsolved hurdle in cancer treatment, with greater than 90% of cancer-related deaths attributed to metastasis. In order for cells to successfully metastasize, they must dynamically ...
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(2015-03-09)Department: Cancer BiologyLIM domain Only-2 (LMO2) is a T cell oncogene whose molecular mechanism for T-cell transformation still remains to be elucidated. There are two hypotheses that could explain how the enforced expression of LMO2 induces ...
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(2022-05-10)Department: Cancer BiologyA crucial challenge in the care of cancer patients is identifying which treatment is most likely to benefit, and least likely to harm, each individual cancer patient. Herein, I present two projects: one which seeks to ...
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(2011-02-15)Department: Cancer BiologyHelicobacter pylori infection persists for the life of the host due to the failure of the immune response to eradicate the bacterium. Determining the mechanisms by which the bacterium escapes the immune response are ...
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(2005-12-19)Department: Cancer BiologyCANCER BIOLOGY BCL-2/BCL-XL REGULATES CELL CYCLE THROUGH A NOVEL MECHANISM IN ADDITION TO CELL SURVIVAL YELENA MELKUM JANUMYAN Dissertation under the direction of Professor Elizabeth Yang Bcl-2 and Bcl-xL are ...
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(2010-04-20)Department: Cancer BiologyThe major goal of this thesis is to examine the role of beta1 integrin in kidney development. Our results indicate that beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting ...
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(2019-09-19)Department: Cancer BiologyBlood vessel epicardial substance (BVES or POPDC1) is a tight junction-associated adhesion molecule that regulates epithelial-mesenchymal transition and is downregulated in colorectal cancer via promoter hypermethylation, ...
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(2008-01-18)Department: Cancer BiologyThese studies examine the consequences of tissue-specific oncogene or a tumor suppressor gene expression in either human prostatic epithelial or stromal cells. This approach allows us to monitor the growth and differentiation ...
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(2012-05-03)Department: Cancer BiologyC/EBPbeta is a member of a family of basic-leucine zipper transcription factors. It has been shown to be a key regulator of growth and differentiation in the mammary gland. There are three different protein isoforms of ...
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(2012-08-31)Department: Cancer BiologyThese studies tested the hypothesis that cell-extracellular matrix (ECM) interactions promote the maturation of invadopodia to fully functional structures. I demonstrate that invadopodia-associated ECM degradation is ...
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(2014-12-31)Department: Cancer BiologyNon alcoholic fatty liver disease (NAFLD), is recognized as the one of the most common causes of liver disease in the United States and worldwide. NAFLD is associated with increased risk of development of hepatocellular ...
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(2017-04-11)Department: Cancer BiologyMelanoma is the deadliest form of skin cancer, and virtually all patients progress on targeted therapies. Dysregulated metabolism has been shown to affect therapy response, so BRAF-mutated melanoma cell line models were ...
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(2021-08-13)Department: Cancer BiologyMetabolism underpins many processes in cellular biology. Many diseases including cancer often involve aberrant metabolic pathways with altered reliance on metabolites, metabolic enzymes, or metabolic regulators. B lymphocytes ...
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(2006-12-01)Department: Cancer BiologyTransforming Growth Factor-β (TGF-β) is a cytokine involved in the regulation of multiple cellular responses, and it is accepted that the TGF-β signaling pathway is implicated in both tumor-suppressing and tumor-promoting ...