Browsing by Department "Cancer Biology"
Now showing items 21-40 of 155
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(2007-08-14)Department: Cancer BiologyCyclooxygenase-2 (COX-2) has long been known to be a facilitator of colorectal neoplasia, specifically in the development and progression of adenomatous polyps to colorectal carcinoma. The purpose of the studies conducted ...
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(2015-04-13)Department: Cancer BiologyCANCER BIOLOGY Critical Regulators of Epithelial Homeostasis and Intestinal Crypt Regeneration: Identification of Novel BVES/BCAR3 Signaling Complex in EMT and Tumorigenesis and Biological Implications for MTG16 in Stem ...
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(2022-05-17)Department: Cancer BiologyThe tumor microenvironment (TME) is rich with proliferating tumor cells and infiltrating immune cells. In these niches, glucose, glutamine, and fatty acids are consumed. However, it was previously underappreciated to what ...
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(2014-07-23)Department: Cancer BiologyThere is a major need to better understand the molecular basis of triple negative breast cancer (TNBC) in order to develop effective therapeutic strategies. Using gene expression data from 587 TNBC patients we previously ...
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(2008-03-19)Department: Cancer BiologyGastric adenocarcinoma is the second leading cause of cancer-related death in the world, and infection with Helicobacter pylori is the strongest known risk factor for this malignancy. Adherence of H. pylori to gastric ...
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(2009-11-13)Department: Cancer BiologyGastric adenocarcinoma is strongly associated with the presence of H. pylori. Microbial factors of H. pylori and host responses induced by the interactions of H. pylori with gastric epithelial cells play important roles ...
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(2013-09-23)Department: Cancer BiologyInflammatory bowel disease (IBD), which affects 1 in 600 Americans, is characterized by severe and chronic inflammation, a known contributor to cancer. As such, the risk for cancer is increased in patients with IBD compared ...
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(2009-07-07)Department: Cancer BiologyBreast to bone metastasis is a common event during breast cancer progression. The resultant lesions often cause extensive bone destruction that results in a number of complications including intense pain that dramatically ...
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(2012-07-26)Department: Cancer Biologyp120-catenin (p120) is a master regulator of cellular adherens junctions and is important for epithelial homeostasis, development, tumorigenesis, and metastasis. Relatively little is known about the different functions of ...
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(2014-03-28)Department: Cancer BiologyThe adult mammalian brain hosts two regions of quiescent neural stem cells that continually generate new neurons throughout life. One of these regions, the subventricular zone (SVZ), primarily produces immature neuroblasts ...
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(2013-10-11)Department: Cancer BiologyDissertation under the direction of Professor Harold L. Moses Transforming Growth Factor Beta (TGF-β) is acts as both a tumor suppressor and promoter in the context of epithelial tumor progression. In epithelial cells, ...
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(2017-04-12)Department: Cancer BiologyLung cancer is the leading cause of cancer deaths worldwide. More than 40% of lung cancers are classified as lung adenocarcinoma (LUAD), which is defined by pathological characteristics. Oncogenic mutations in the epidermal ...
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(2008-04-07)Department: Cancer BiologyColon cancer progression is frequently characterized by activating mutations in Ras and emergence of the tumor promoting effects of TGF-beta signaling. Ras-inducible rat intestinal epithelial cells (RIE:iRas) undergo a ...
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(2011-04-18)Department: Cancer BiologyEph receptor tyrosine kinases are membrane bound receptors often expressed by normal epithelial cells but are frequently overexpressed in many human cancers. Of the many Eph receptors, EphA2 is present at low levels in ...
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(2020-11-18)Department: Cancer BiologyThe American Cancer Society estimates that over 250,000 new cases of invasive breast cancer are diagnosed annually in the United States. Subtyping breast cancer and the identification of targeted therapies have greatly ...
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(2023-07-14)Department: Cancer BiologySmall cell lung cancer (SCLC) is a phenotypically heterogeneous disease, comprising multiple cellular subtypes within a tumor that exhibit differential sensitivity to drug treatments. SCLC heterogeneity is hypothesized to ...
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Focal Adhesion Kinase Mediates Gastrin-Releasing Peptide Receptor-Induced Neuroblastoma Progression (2013-04-18)Department: Cancer BiologyNeuroblastomas express increased levels of gastrin-releasing peptide receptor (GRPR). However, the exact molecular mechanisms involved in GRPR-mediated cell signaling in neuroblastoma growth and metastasis are unknown. In ...
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(2009-04-21)Department: Cancer BiologyFUNCTIONAL STUDIES ON INTERLEUKIN 24 IN VITRO AND IN VIVO MIAO HE Thesis under the direction of Professor Peng Liang Among IL-20 family of cytokines, IL-19, IL-20 and IL-24 can each activate IL20R1/IL-20R2 heterodimeric ...
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(2008-03-05)Department: Cancer BiologyThere is a significant genetic component to prostate cancer (PrCa) risk. Multiple epidemiologic and linkage studies suggest X-linked heritability. Located at chromosome Xq27-28, HPCX has been identified as a PrCa susceptibility ...
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(2023-10-23)Department: Cancer BiologySarcomas are a rare family of tumors derived from mesenchymal tissues including bone, fat, cartilage, and muscle. Sarcomas vary significantly across histological and molecular subtypes, making them difficult to treat ...