Browsing by Author "D. Borden Lacy"
Now showing items 1-18 of 18
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Lojek, Lisa J (2017-11-30)Department: Microbiology and ImmunologyThe goal of this thesis was to investigate the role of the IsdG family of heme oxygenases within microbial cells. In Chapter II, I identified the first IsdG family member in a eukaryotic organism and expanded the IsdG ...
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Fites, Jeffrey Scott (2014-03-04)Department: Biological SciencesIn the sixth mass extinction, amphibians are being lost in greater numbers than almost any other taxon. The deadly skin disease, chytridiomycosis, has taken a great toll on amphibian populations around the globe. ...
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Branch, Megan Christine (2011-07-07)Department: BiochemistryGenome sequencing projects have revealed that glutathione (GSH) transferases are widely distributed in bacteria but most remain only as annotations in sequenced genomes. The goal of this project was to assign function to ...
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Craven, Ryan Eric (2016-03-04)Department: Microbiology and ImmunologyClostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. The two principle virulence factors, TcsH and TcsL, are highly homologous to C. difficile TcdA and TcdB, ...
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Choby, Jacob Edward (2019-01-25)Department: Microbiology and ImmunologyThe cofactor heme is essential to the growth and virulence of the human pathogen Staphylococcus aureus. S. aureus is capable of synthesizing heme de novo as well as acquiring it from host hemoglobin. The molecular mechanisms ...
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Pishchany, Glib (2011-06-09)Department: Microbiology and ImmunologyMICROBIOLOGY AND IMMUNOLOGY HUMAN HEMOGLOBIN AS AN IRON SOURCE OF STAPHYLOCOCCUS AUREUS GLIB PISHCHANY Dissertation under the direction of Professor Eric P. Skaar Staphylococcus aureus is a tremendous human pathogen ...
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Chandrasekaran, Ramyavardhanee (2017-11-27)Department: Microbiology and ImmunologyClostridium difficile infection affects a significant number of hospitalized patients in the United States. Two homologous exotoxins, TcdA and TcdB, are the major virulence factors in C. difficile pathogenesis. The toxins ...
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Mushrush, Darren J (2011-09-06)Department: BiochemistryBotulinum neurotoxin (BoNT) belongs to a large class of toxic proteins that act by enzymatically modifying cytosolic substrates within eukaryotic cells. The process by which a catalytic moiety is transferred across a ...
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Mike, Laura Anzaldi (2013-10-01)Department: Microbiology and ImmunologyStaphylococcus aureus and Bacillus anthracis are two closely related Gram positive pathogens. The pathogenesis of each of these bacteria often involves a significant blood component. In the blood, both S. aureus and B. ...
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Stauff, Devin (2009-04-20)Department: Microbiology and ImmunologyThe human pathogen Staphylococcus aureus is capable of acquiring heme during infection for use as a source of iron, a nutrient that is scarce in its free form in host tissues. However, heme acquisition is dangerous to ...
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Shaffer, Carrie Leigh (2011-11-22)Department: Microbiology and ImmunologyColonization of the human stomach by Helicobacter pylori is an important risk factor for development of gastric cancer. The H. pylori cag pathogenicity island (cag PAI) encodes components of a type IV secretion system ...
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Pruitt, Rory Nelson (2011-09-13)Department: Microbiology and ImmunologyThe pathogenesis of Clostridium difficile is dependent on two large homologous toxins, TcdA and TcdB. These toxins contain glucosyltransferase domains that inactivate host Rho proteins by glucosylation. Delivery of the ...
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Benefield, Desirée Allyn (2014-07-03)Department: Microbiology and ImmunologyMy project has focused on understanding the structural organization of the clostridial neurotoxins, botulinum and tetanus, that are the causative agents of the neuroparalytic diseases botulism and tetanus. Once the toxins ...
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Gonzalez-Rivera, Christian (2013-04-08)Department: Microbiology and ImmunologyHelicobacter pylori colonizes the human stomach and is associated with an increased risk of peptic ulcer disease, gastric adenocarcinoma, and gastric lymphoma. An important virulence factor produced by Helicobacter pylori ...
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Flyak, Andrew I. (2016-06-21)Department: Microbiology and ImmunologyFiloviruses cause a highly lethal disease in humans, with untreated mortality rates approaching 90%. Most of our knowledge about neutralizing antibody responses against filovirus infections has come from studies of monoclonal ...
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Stencel-Baerenwald, Jennifer (2014-11-24)Department: Microbiology and ImmunologyVirus-receptor interactions govern the susceptibility of cells to infection and dictate viral tropism in the host. Mammalian reoviruses display serotype-specific neurotropism in newborn mice, with serotype 1 (T1) strains ...
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Reniere, Michelle Lynne (2010-04-12)Department: Microbiology and ImmunologyStaphylococcus aureus is an important human pathogen and its ability to cause disease is absolutely dependent on iron acquisition from the host. S. aureus obtains iron during infection from vertebrate hemoglobin via the ...
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Ashbrook, Alison Whitney (2015-07-21)Department: Microbiology and ImmunologyChikungunya virus (CHIKV) is a mosquito-borne cause of epidemics of debilitating arthritis worldwide. Currently, there are no licensed vaccines or antiviral therapies available for the prevention or treatment of CHIKV ...