Browsing by Author "Christopher R. Aiken"
Now showing items 1-6 of 6
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Lai, Caroline Ming-Hwei (2013-12-04)Department: Microbiology and ImmunologyBloodstream spread is an essential step in the pathogenesis of many viruses. However, mechanisms that promote viremia are not well understood. Reoviruses are neurotropic viruses that disseminate systemically through the ...
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Chandrasekaran, Ramyavardhanee (2017-11-27)Department: Microbiology and ImmunologyClostridium difficile infection affects a significant number of hospitalized patients in the United States. Two homologous exotoxins, TcdA and TcdB, are the major virulence factors in C. difficile pathogenesis. The toxins ...
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Sexton, Nicole Rose (2017-04-07)Department: Microbiology and ImmunologyAll positive sense (+)RNA viruses encode RNA-dependent RNA polymerases (RdRps), essential for replication and regulation of the fidelity of nucleotide addition to nascent genomes. The coronavirus (CoV) RdRp is encoded in ...
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Stobart, Christopher Colin (2013-10-18)Department: Microbiology and ImmunologyCoronaviruses (CoV) are positive-strand RNA viruses that encode large replicase polyproteins that are processed by two or three viral proteases to yield intermediate and mature nonstructural proteins (nsps). Nsp5 (3CLpro, ...
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Briney, Bryan Scott (2012-07-30)Department: Microbiology and ImmunologySeveral of the most broadly neutralizing HIV antibodies (bnAbs) contain unique genetic or structural elements, including long heavy chain complementarity determining region 3 (HCDR3) loops and extensive somatic hypermutation. ...
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Ashbrook, Alison Whitney (2015-07-21)Department: Microbiology and ImmunologyChikungunya virus (CHIKV) is a mosquito-borne cause of epidemics of debilitating arthritis worldwide. Currently, there are no licensed vaccines or antiviral therapies available for the prevention or treatment of CHIKV ...