Browsing by Author "Borden Lacy"
Now showing items 1-11 of 11
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Cox, Reagan Josephine Greene (2012-12-07)Department: Microbiology and ImmunologyThis project is concerned with how the recently discovered paramyxovirus, human metapneumovirus (HMPV), interacts with host cells to initiate entry. In this dissertation I explore whether the HMPV fusion protein interacts ...
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Deatherage, Catherine Laura (2016-03-29)Department: BiochemistryBIOCHEMISTRY Comparative Biochemical and Structural Analysis of the Alzheimer’s Disease Related Proteins: Amyloid Precursor Protein and Notch 1. Catherine Laura Deatherage Dissertation under the direction of Professor ...
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Perry, Evan Thomas (2019-03-15)Department: BiochemistryCTLA-4 and PD-1 are immune checkpoints that inhibit T cell activity to maintain immune homeostasis. These checkpoints have also emerged as highly validated cancer targets to stimulate immune responses against cancer. Despite ...
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Carnes, Stephanie Kaye (2019-03-20)Department: Microbiology and ImmunologyHIV-1 infection depends on efficient intracytoplasmic transport of the incoming viral core to the target cell nucleus. Evidence suggests that this movement is facilitated by the microtubule motor dynein, a large multi-protein ...
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Bennett, Monique Renee (2019-09-13)Department: Microbiology and ImmunologyNutrient acquisition is important for the survival of all living organisms. Nutrient metals such as iron, is known to play key roles in cellular metabolism, respiration, and both redox and non-redox catalysis. One particularly ...
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DeLuca, Stephanie Judith Han Hirst (2015-03-25)Department: Chemical and Physical BiologyMembrane proteins remain a particular challenge in structural biology. Only approximately 1.5% of reported tertiary structures and around 100 unique polytopic membrane proteins are represented in the Protein Data Bank ...
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Kazmier, Kelli Nicole (2013-12-13)Department: Chemical and Physical BiologyThis thesis has been focused on understanding structure-function relationships of transport proteins and the development of hybrid computational and spectroscopic approaches to understanding protein biology. The widespread ...
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Rubinson, Emily Holtzman (2011-02-17)Department: Chemical and Physical BiologyAlkylating agents covalently modify DNA bases to generate a chemically diverse set of lesions including cytotoxic N3-methyladenine (3mA) bases and mutagenic 1,N6-ethenoadenine (εA) and N7-methylguanine (7mG). To maintain ...
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Amadi, Sepan Tariq Hassan (2010-06-29)Department: Molecular Physiology and BiophysicsThe multidrug transporter EmrE is a proton coupled secondary transporter from Escherichia coli. EmrE confers resistance to a variety of positively charged hydrophobic cations by removing them out of the cell in exchange ...
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Frick-Cheng, Arwen Elise (2017-03-30)Department: Microbiology and ImmunologyBacterial type IV secretion systems (T4SSs) can function to export or import DNA, and can deliver effector proteins into a wide range of target cells. Relatively little is known about the structural organization of T4SSs ...
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Johnson, Elizabeth Rose Meade (2009-09-25)Department: Microbiology and ImmunologyThe cathepsin family of endosomal proteases is required for proteolytic processing of several viruses during entry into host cells. Mammalian reoviruses utilize cathepsins B, L, and S for disassembly of the virus outer ...