Browsing by Author "Barbara Fingleton"
Now showing items 1-20 of 25
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Pruitt, Freddie Lee (2013-06-28)Department: Cancer BiologyStromal-epithelial interactions are important in both prostate development and cancer. Stromal changes have been shown to be powerful prognostic indicators of prostate cancer progression and of patient death helping to ...
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Hebron, Katie Elizabeth (2018-03-27)Department: Cancer BiologyMetastasis persists as a significant unsolved hurdle in cancer treatment, with greater than 90% of cancer-related deaths attributed to metastasis. In order for cells to successfully metastasize, they must dynamically ...
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Lewis, Nuruddeen (2011-02-15)Department: Cancer BiologyHelicobacter pylori infection persists for the life of the host due to the failure of the immune response to eradicate the bacterium. Determining the mechanisms by which the bacterium escapes the immune response are ...
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Mendonsa, Alisha Maria (2014-12-31)Department: Cancer BiologyNon alcoholic fatty liver disease (NAFLD), is recognized as the one of the most common causes of liver disease in the United States and worldwide. NAFLD is associated with increased risk of development of hepatocellular ...
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Barrett, Caitlyn Whitten (2013-09-23)Department: Cancer BiologyInflammatory bowel disease (IBD), which affects 1 in 600 Americans, is characterized by severe and chronic inflammation, a known contributor to cancer. As such, the risk for cancer is increased in patients with IBD compared ...
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Pickup, Michael William (2013-10-11)Department: Cancer BiologyDissertation under the direction of Professor Harold L. Moses Transforming Growth Factor Beta (TGF-β) is acts as both a tumor suppressor and promoter in the context of epithelial tumor progression. In epithelial cells, ...
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McFadden, Ian David (2014-11-26)Department: Interdisciplinary Materials ScienceCancer, a diagnosis that encompasses over 200 different disease states classified as malignant neoplasms, is poised to become the leading cause of death in the United States. Many of these diseases arise in the form of ...
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Elion, David Len (2019-11-14)Department: Cancer BiologyRIG-I is a cytoplasmic RNA helicase expressed in most cells of the body, functioning to sense viral oligonucleotide motifs then activate innate immune responses to combat viral infection. RIG-I expression and activity is ...
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Ogden, Seth Rayborn (2009-03-03)Department: Cancer BiologyGastric adenocarcinoma is strongly associated with the presence of H. pylori, and both microbial and host factors influence the risk for carcinogenesis. A novel role for H. pylori in the stimulation of the p120ctn/Kaiso ...
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Ortega, Ryan Adam (2014-11-25)Department: Biomedical EngineeringTumor associated macrophages (TAMs) play an important role in establishing a pro-tumor environment in many tumor types. Produce low levels of inflammatory cytokines which creates pro-tumorigenic smoldering inflammation and ...
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Petersen, Christine Pope (2016-03-30)Department: Cell and Developmental BiologySpasmolytic polypeptide-expression metaplasia (SPEM) develops in the atrophic stomach and progresses to an intestinalized SPEM in the setting of inflammation. Different immune deficient mouse models determined that T-cells, ...
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Saxon, Jamie Ausborn (2016-02-19)Department: Cancer BiologyNuclear factor κ-light chain enhancer of activated B cells (NF-κB) is a transcription factor that can be activated through canonical or non-canonical signaling pathways, and activation of both pathways has been observed ...
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Clements, Miranda (2019-03-29)Department: Cancer BiologyDespite the high prevalence of breast cancer metastasis to bone, there are currently no therapeutic options to cure metastatic disease. This deficit is in part due to the lack in vivo models that recapitulate prolonged ...
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Dear, Mary Lynn (2018-01-16)Department: Biological SciencesSynaptogenesis requires coordinated intercellular communication between a presynaptic neuron and postsynaptic target cell. Neural development and maintenance is driven by a wide variety of molecules that necessarily traverse ...
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Sinnamon, Mark J (2008-04-22)Department: Cancer BiologyMatrix metalloproteinases (MMPs) are classically associated with late stage metastases, though previous work by our lab and others have expanded the role of MMPs to all stages of tumor development. Using a genetic model ...
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Nielsen, Casey Paulasue (2019-09-09)Department: Cell and Developmental BiologyThe WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...
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Garcia, Christina Valerie Boma (2011-09-26)Department: Cancer BiologySynovial sarcoma (SS) is a rare but aggressive malignancy that is typically diagnosed in adolescents and young adults. These tumors are characterized by the presence of a specific chromosomal translocation t(X;18)(p11.2;q11.2) ...
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Bissonnette, Adam Marc (2018-04-12)Department: Cancer BiologyCell motility is a process tightly linked to tumor metastasis. The p21-activated kinases (PAKs) are modulators of cell motility commonly overexpressed and hyperactive in various malignancies. We investigated whether ...
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Lin, Luping (2011-11-08)Department: Cancer BiologyDysregulation of the Notch signaling pathway plays an important role in lung cancer pathobiology. The Notch3 receptor is overexpressed in ∼40% of resected non-small cell lung cancers, and its suppression results in loss ...
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Youngblood, Victoria Marie (2016-03-30)Department: Cancer BiologyDysregulation of receptor tyrosine kinases (RTKs) contributes to cellular transformation and cancer progression by disrupting key metabolic signaling pathways. The EPHA2 RTK is overexpressed in aggressive forms of breast ...