Browsing by Title
Now showing items 14056-14075 of 17747
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(2023-01-09)Department: ChemistrySince the discovery that nonsteroidal anti-inflammatory drugs (NSAIDs) prevent pain, swelling, and inflammation by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), there has been interest in ...
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(2013-04-15)Department: Chemical and Physical BiologyThe topological structure of DNA is regulated by ubiquitous enzymes called topoisomerases. Type II topoisomerases resolve supercoils and remove knots and tangles from the genetic material by generating transient breaks in ...
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(2022-06-09)Department: Computer ScienceThe past decade has witnessed a dramatic rise in the adoption of electronic medical record (EMR) systems. EMR data assists in the development and evaluation of clinical information systems, supports novel biomedical research, ...
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(2021-05-10)Department: Cancer BiologyClear cell renal cell carcinoma (ccRCC) is the most common kidney tumor, and its incidence continues to rise. Elucidation of the molecular biology and the tumor microenvironment (TME) have revolutionized the treatment ...
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(2014-03-21)Department: ChemistryFeglymycin is a tridecapeptide that has been shown to act as an inhibitor of the formation of HIV syncytia as well as the cell-to-cell transmission of the virus. The natural product contains thirteen amino acid residues, ...
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(2016-04-07)Department: ChemistryThe rational design of hybrid nanoparticles is a powerful tool in harnessing nanoscale properties of several different materials in a single whole. The first portion of this work describes the synthesis of dual-plasmonic ...
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Synthetic Strategies Toward Complex Molecule Synthesis: from Glycan Mimetics to Complex Terpenoids (2024-03-08)Department: ChemistryGlycans are ubiquitously expressed on the surface of cells and are responsible for mediating a host of critical cellular interactions. Specifically, bacteria have evolved to produce a diverse array of carbohydrate structures ...
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(2009-10-20)Department: ChemistryAs a selective apoptosis inducer, apoptolidin A was isolated from Nocardiopsis Sp. by Japanese chemists in 1997. Khosla and coworkers have demonstrated that apoptolidin A could inhibit the activity of mitochondrial F0F1-ATP ...
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(2021-05-05)Department: ChemistryNatural products have a long history of serving as therapeutic leads (e.g. taxol and compactin) and biological tools (e.g. rapamycin and oligomycin). Bielschowskysin is a rare and structurally complex marine diterpene, ...
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Synthetic Studies on Hemiketal E2 and 5-Hydroxy Prostaglandin E2 Novel Arachidonic Acid Metabolites (2021-10-06)Department: ChemistryThe metabolites of arachidonic acid have long been studied for their intimate role in the human body inflammatory pathway. Inflammation is the body’s natural defense against foreign pathogens and maintains the body’s ability ...
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(2021-06-11)Department: ChemistryProgress toward the total synthesis of the manzamine alkaloid xestocyclamine A is described. Due to the architecturally interesting structures and biological activity of the manzamine alkaloids, xestocyclamine A remains ...
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(Vanderbilt University, 2010)Abstract: Syphilis has re-emerged as a global public health issue. In lesser developed countries, millions of people are contracting the disease, which can be fatal without access to proper treatment. In developed countries, ...
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(2022-11-18)Department: Civil EngineeringIntelligent Transportation Systems (ITS) have become increasingly important over time demonstrating a need for smarter algorithms to be deployed in Integrated Corridor Management (ICM). Two Active Traffic Management (ATM) ...
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(2017-07-20)Department: Mechanical EngineeringThe motivation for this dissertation is to provide surgeons with more capable tools during minimally invasive surgery. Specifically, this work is focused on the design of robotic systems that provide flexible, multi-arm ...
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(2006-05-02)Department: Electrical EngineeringThe focus of this work was the development of equipment and image processing techniques to observe the melting characteristics at the leading edge of a gas tungsten arc weld. A high speed digital imaging system, along with ...
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(2016-11-28)Department: Electrical EngineeringThere is increasing interest in using commercial-off-the-shelf (COTS) electronics in radiation environments, such as robotic systems for remediation after the nuclear accident at Fukushima or in low-cost CubeSats. Commercial ...
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(2013-08-12)Department: Civil EngineeringThis dissertation develops a methodology that provides information to make optimal decisions with respect to the mission and maintenance of a system. A great amount of information is needed about a system to make such ...
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(2013-09-12)Department: Electrical EngineeringIn a radiation environment analog circuits are particularly susceptible to radiation effects, due to stringent requirements on signal integrity and precision. This dissertation demonstrates system-level radiation-hardeni ...
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(2022-03-21)Department: Biomedical SciencesThe B-cell repertoire within an individual is a library of antibodies to all the pathogens an individual had been exposed to in the past. Many methods have been implemented to dig into this rich source of antibodies to ...