Search
Now showing items 1-6 of 6
Spatially-Resolved Proteomics of the Human Lens: Mapping Age- and Development-Related Lens Protein Modifications
(2016-02-29)
The ocular lens is a transparent optical element that focuses light onto the retina for clear vision. The bulk of the lens is composed of elongated, anuclear fiber cells, which are continuously synthesized throughout life ...
Proteomic Signatures of Epidermal Growth Factor Receptor Signaling
(2012-01-25)
Analysis of cellular signaling networks typically involves targeted
measurements of phosphorylated protein intermediates. However,
phosphoproteomic analyses usually require affinity enrichment of
phosphopeptides and ...
Identification of protein markers of drug-induced nephrotoxicity by MALDI MS: in vivo discovery of ubiquitin-t
(2009-04-09)
This study demonstrated the utility of direct tissue MALDI MS in identifying early markers of antibiotic induced nephrotoxicity. Using a histology directed approach, twelve proteins were identified as having statistically ...
Genetic and biochemical analysis of the interaction between the yeast fatty acid synthesis enzyme YBR159W and the translation initiation complex eIF2B
(2013-06-04)
This dissertation focuses on the biochemical and genetic characterization of the protein-protein interaction in the budding yeast Saccharomyces cerevisiae between the cytosolic translation initiation guanine nucleotide ...
Dynamic Regulation of Apoptosis Signal-Regulating Kinase 1
(2016-04-06)
Apoptosis signal-regulating kinase 1 (ASK1) is a critical sensor of cellular stress that is capable of integrating several chemically distinct signals into a single response pathway and is believed to play a role in several ...
Assessing the Components of the eIF3 Complex and Their Phosphorylation Status
(2011-12-09)
BIOCHEMISTRY
ASSESSING THE COMPONENTS OF THE eIF3 COMPLEX AND THEIR PHOSPHORYLATION STATUS
ADAM RICHARD FARLEY
Dissertation under the direction of Professor Andrew J. Link
The eukaryotic initiation factor 3 (eIF3) is ...