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Biochemical and structural analysis of SV40 Large T antigen: insights into chaperone mediated inactivation of retinoblastoma tumor suppressor protein
(2012-03-28)
Simian Virus 40 uses its Large T antigen protein to bind and inactivate retinoblastoma tumor suppressor proteins, yielding cell transformation. T antigen is a modular protein with four domains connected by linkers. The ...
NMR Resonance Assignments and Secondary Structure of a Mutant Form of the Human KCNE1 Channel Accessory Protein that Exhibits KCNE3-like Function
(2019-03-28)
KCNQ1 (Q1), a voltage-gated potassium channel, is modulated by members of the KCNE family, the best-characterized being KCNE1 (E1) and KCNE3 (E3). The Q1/E1 complex generates a channel with delayed activation and increased ...
Structural and functional analysis of the U-box domain of the E4B ubiquitin ligase
(2011-08-31)
Ubiquitination is a post-translational modification, that functions in a variety of cellular signaling pathways. Unlike modification with a small functional group by a single enzyme, modification by the small protein ...
Comparative Biochemical and Structural Analysis of the Alzheimer’s Disease Related Proteins: Amyloid Precursor Protein and Notch1.
(2016-03-29)
BIOCHEMISTRY
Comparative Biochemical and Structural Analysis of the Alzheimer’s Disease Related Proteins: Amyloid Precursor Protein and Notch 1.
Catherine Laura Deatherage
Dissertation under the direction of Professor ...
The Interactions of Two Disease-Linked Membrane Proteins with Their Bilayer Milieu
(2015-07-17)
This project is concerned with the study of human integral membrane proteins involved in neurodegenerative disorders. In this dissertation, I explore the synergistic interactions between membrane proteins and their resident ...
Development and application of a high-throughput biophysical approach to study transmembrane protein interactions with small molecules
(2022-06-13)
Alzheimer’s disease (AD) is the most common form of dementia in the U.S. with no disease-modifying therapies. A key hallmark of AD is the generation of amyloid-β (Aβ) peptides and plaques, which have long been thought to ...