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Elucidating the mechanism of action of selective histone deacetylase inhibitors in cancer
(2013-04-09)
Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored ...
Biochemical and structural analysis of the p58C and p68N domains of DNA polymerase alpha/primase
(2008-07-28)
The replication of DNA occurs through a complex series of steps involving the coordinated action of many proteins. DNA polymerase alpha/primase (pol-prim) is a critical DNA replication factor that synthesizes short RNA-DNA ...
Regulation of replication fork stability by ssDNA binding proteins
(2018-02-26)
The replication stress response (RSR) maintains genome stability and promotes the accurate duplication of the genome. ssDNA binding proteins are integral components of the RSR and have been extensively studied for years. ...
Human Topoisomerases and DNA Geometry: Putting a Positive Twist on Enzyme Action
(2006-04-12)
HUMAN TOPOISOMERASES AND DNA GEOMETRY: PUTTING A POSITIVE TWIST ON ENZYME ACTION
AMY KATHLEEN MCCLENDON
Topoisomerases play critical roles in maintaining DNA topology during cellular processes such as DNA replication ...
Regulation of ATR Signaling by CINP and RPA
(2009-05-28)
Genetic instability is a hallmark of cancer. The ATR-ATRIP complex functions at the apex of a cell cycle checkpoint signaling pathway that is critical during every cell division cycle to maintain genome integrity. ATR ...
Regulation of Stalled Replication Forks by ATR
(2014-04-17)
Errors during DNA replication lead to mutations which contribute to cancer development. To deal with these challenges, cells contain an innate machinery known as the replication stress response. ATR is the master regulator ...
Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA)
(2013-07-12)
The in vivo analysis of dynamic events that protect genomic and epigenomic integrity during DNA replication has been a challenging task. The proteins that ensure the accurate inheritance of the genome act directly at ...
A common mechanism of ATR activation by TOPBP1 and ETAA1
(2021-02-12)
Human cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...