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Identifying and defining the genome maintenance functions of SMARCAL1
(2012-06-15)
In this dissertation I identify and define SWI/SNF, matrix-associated, actin-dependent regulator of chromatin, A-like 1 (SMARCAL1) as a genome maintenance protein. First, I introduce a functional genomic screen designed ...
Regulation of ATR Signaling by CINP and RPA
(2009-05-28)
Genetic instability is a hallmark of cancer. The ATR-ATRIP complex functions at the apex of a cell cycle checkpoint signaling pathway that is critical during every cell division cycle to maintain genome integrity. ATR ...
Regulation of Stalled Replication Forks by ATR
(2014-04-17)
Errors during DNA replication lead to mutations which contribute to cancer development. To deal with these challenges, cells contain an innate machinery known as the replication stress response. ATR is the master regulator ...
SMARCAL1 Maintains Telomere Integrity During DNA Replication
(2017-11-08)
DNA replication is constantly challenged by several sources of replication stress that can affect the accuracy and timely completion of this essential biological process. The DNA damage response (DDR) exists to address ...
Regulation of the ATR Pathway in the Replication Stress Response
(2016-07-15)
Every cell divisions cycle, over 6.8 billion base pairs of DNA must be accurately replicated. To further complicate this process, the DNA is damaged at a rate of ~10,000 lesions per cell per day. To overcome these obstacles, ...
A common mechanism of ATR activation by TOPBP1 and ETAA1
(2021-02-12)
Human cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...