Search
Now showing items 1-6 of 6
Formation, Degradation, and Bypass of DNA-Protein Crosslinks
(2018-09-18)
The preservation of DNA replication is requisite for cellular integrity and prevention of tumor formation and cell death. The Y-family DNA polymerases (Pol eta, kappa, iota, and REV1) are crucial in this process because ...
DNA Lesions as Cellular Poisons of Topoisomerase II-alpha
(2005-11-02)
Topoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...
DNA-Protein Cross-Links Induced by Bis-Electrophiles
(2010-04-30)
Diepoxybutane is a mutagenic and carcinogenic oxidation product of the important industrial chemical and environmental contaminant butadiene. The mutagenic potential of diepoxybutane is thought to be due in part to its ...
ETAA1 promotes genome stability through activation of ATR
(2018-11-21)
The ATR kinase controls cell cycle transitions and the DNA damage response. Budding yeast contain three activators of Mec1ATR; however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication ...
Identification and regulation of p53 target genes in primary human epidermal keratinocytes
(2006-12-07)
BIOCHEMISTRY
IDENTIFICATION AND REGULATION OF P53 TARGET GENES IN PRIMARY HUMAN EPIDERMAL KERATINOCYTES
KRISTY L. SCHAVOLT
Dissertation under the direction of Professor Jennifer A. Pietenpol
The p53 tumor suppressor ...
Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA)
(2013-07-12)
The in vivo analysis of dynamic events that protect genomic and epigenomic integrity during DNA replication has been a challenging task. The proteins that ensure the accurate inheritance of the genome act directly at ...