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Role of DNA interactions in modulating the activity of human topoisomerases and anticancer drugs
(2011-03-18)
Human topoisomerase I and topoisomerase IIα and IIβ play critical roles in regulating the topological state of DNA and are targets for some of the most widely prescribed anticancer drugs currently in clinical use. These ...
DNA Lesions as Cellular Poisons of Topoisomerase II-alpha
(2005-11-02)
Topoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...
Characterization of SRAP Domain DNA-Protein Crosslink Formation and Reversal with DNA Abasic Sites
(2022-06-27)
Apuirinic/apyrimidinic (AP, or abasic) sites in DNA are one of the most common forms of DNA damage. AP sites are reactive and form crosslinks to both proteins and DNA, are prone to strand breakage, and inhibit DNA replication ...
Replication Fork Uncoupling Causes Nascent Strand Degradation and Fork Reversal
(2022-11-22)
Genotoxic agents can cause nascent strand degradation (NSD) and fork reversal during DNA replication. NSD and fork reversal are crucial biochemical mechanisms that maintain genome stability and they are frequently exploited ...