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There and Back Again: A Protein’s Tale Uncovering the Quality Control Factors Mediating Peripheral Myelin Protein 22 Trafficking
(2020-11-02)
Charcot-Marie Tooth disease (CMTD) is the most common inherited neuropathy of the peripheral nervous system (PNS) and afflicts roughly 1 in 2,500 individuals. Over 70% of patients afflicted with this disease have a mutation ...
Early Events in RNA Virus Infection: Profiling the Pre-Replicated Interactome of Chikungunya Virus
(2020-11-05)
The race between RNA virus replication and the host innate immune response begins immediately after viral infection. While awaiting transcriptional upregulation of interferons and antiviral genes, cells must rely on mRNAs ...
Regulation of iron homeostasis by the sulfur assimilation pathway
(2020-02-14)
Regulation of iron homeostasis is perturbed in numerous pathologic states. Thus, identifications of mechanisms responsible for iron metabolism have broad implication for disease modification. Sulfur assimilation is an ...
Inhibition of LSD1 as a Therapeutic Strategy for Acute Myeloid Leukemia
(2020-07-20)
Chromatin-modifying enzymes have been identified as promising therapeutic targets for a variety of malignancies. One such target is the histone demethylase Lysine-Specific Demethylase 1 (LSD1), which is found in transcriptional ...
Examination of a mouse model lacking the engulfment receptor Jedi
(2020-03-30)
The dorsal root ganglia (DRG) house the primary afferent neurons responsible for somatosensation, including pain. We previously identified Jedi-1 (PEAR1/MEGF12) as a phagocytic receptor expressed by satellite glia in the ...
Epigenomic Dynamics of Cellular Differentiation
(2020-06-11)
Current models of enhancer dynamics only weakly describe a role for DNA methylation within the ordered process of cellular differentiation and enhancer activation, both frequently perturbed in human disease. However, DNA ...
ANCIENT SRAP DOMAIN SHIELDS ABASIC SITES TO PROMOTE GENOME INTEGRITY
(2020-06-02)
Abasic (AP) sites are one of the most common DNA lesions that can block replicative polymerases. Currently, all known mechanisms for AP site repair function within the context of double-stranded DNA (dsDNA). A newly ...
A common mechanism of ATR activation by TOPBP1 and ETAA1
(2021-02-12)
Human cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...
ELAV(L1)ating Insight into Dynamic mRNA-Protein Interactions in Innate Immunity
(2021-05-10)
Upon pathogen detection, the innate immune system triggers signaling events leading to upregulation of pro-inflammatory and anti-microbial mRNA transcripts. RNA-binding proteins (RBPs) interact with these critical mRNAs ...
Evaluating Mutant p53 Gain-of-function Phenotypes and Mechanisms in Cancer
(2021-10-18)
p53 is mutated in over half of human cancers. In addition to losing wild-type (WT) tumor-suppressive function, mutant p53 proteins are proposed to acquire gain-of-function (GOF) activity, leading to novel oncogenic phenotypes. ...