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Interactions between Angiotensin II and Prostaglandin E2: Mechanisms for Regulation of Vascular Reactivity
(2016-08-05)
Prostaglandin E2 (PGE2), a cyclooxygenase metabolite that generally acts as a systemic vasodepressor, has been shown to have vasopressor effects under certain physiologic conditions. Previous studies have demonstrated that ...
The characterization of the role of myeloid translocation gene 16 in hematopoietic progenitor and stem cell functions
(2011-08-25)
The t(8;21) and t(16;21) that are associated with acute myeloid leukemia disrupt two closely related genes termed Myeloid Translocation Genes 8 (MTG8, also known as ETO) and 16 (MTG16 also known as ETO2), respectively. ...
Mechanistic details of the pH-dependent association of botulinum neurotoxin with membranes
(2011-09-06)
Botulinum neurotoxin (BoNT) belongs to a large class of toxic proteins that act by enzymatically modifying cytosolic substrates within eukaryotic cells. The process by which a catalytic moiety is transferred across a ...
Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer
(2016-11-15)
BIOCHEMISTRY
Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer
Josiah Ewing Hutton, III.
Dissertation under the direction of Professor Daniel C. Liebler
Analysis of cancer cells that have ...
Spatially-Resolved Proteomics of the Human Lens: Mapping Age- and Development-Related Lens Protein Modifications
(2016-02-29)
The ocular lens is a transparent optical element that focuses light onto the retina for clear vision. The bulk of the lens is composed of elongated, anuclear fiber cells, which are continuously synthesized throughout life ...
Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs
(2011-01-14)
The cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion arachidonic acid (AA) to prostaglandin H2 (PGH2), which is the precursor to biologically active prostanoids. The primary mechanism of action of non-steroidal ...
Exploring two new modalities of topoisomerase II-targeting drugs to enhance specificity for cancer cells
(2019-01-18)
Type II topoisomerases are enzymes that transiently cut the DNA to regulate supercoiling and remove knots and tangles from the genome. Although they are essential for cell survivability, these enzymes are potentially ...
The Essential Role of p73 in Multiciliated Cell Development
(2016-03-18)
The pivotal role of the transcription factor p53 in tumor suppression remains unchallenged; however, the role of its family member, p73, in normal cellular function and tumorigenesis is far from certain. The goal of this ...
The catalytic activity of HDAC3 is necessary for a normal rate of cellular proliferation
(2012-04-06)
Histone deacetylases (HDACs) are enzymes that regulate chromatin structure through removal of acetyl groups from lysine residues on histones. HDAC3 is a unique member of class 1 HDACs that is a critical component of the ...
Elucidating the mechanism of action of selective histone deacetylase inhibitors in cancer
(2013-04-09)
Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored ...