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Mechanistic Insights into Fosfomycin Resistance: Examination of the FosX Class of Fosfomycin Resistance Proteins
(2005-12-05)
The objective of this research was to examine the FosX class of metalloenzymes utilized by pathogenic microorganisms for resistance to the antibiotic fosfomycin. Fosfomycin is an extremely stable natural product produced ...
NRIF is an essential component of apoptotic signaling by the p75 neurotrophin receptor
(2005-01-27)
Activation of the p75 neurotrophin receptor leads to a variety of effects within the nervous system, including neuronal apoptosis. Both c-Jun N-terminal kinase (JNK) and the tumor suppressor p53 have been reported to be ...
Mechanisms by which calcium regulates the human cardiac voltage-gated sodium channel hH1
(2005-08-12)
The function of the human cardiac voltage-gated sodium channel hH1 is regulated in part by an EF-hand in its C-terminal cytoplasmic domain. The binding of calcium to the EF-hand results in calmodulin-independent, ...
DNA Lesions as Cellular Poisons of Topoisomerase II-alpha
(2005-11-02)
Topoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...