Browsing Electronic Theses and Dissertations by Department "Molecular Physiology and Biophysics"
Now showing items 1-20 of 101
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(2008-01-17)Department: Molecular Physiology and BiophysicsSmall heat shock proteins (sHSPs) are a ubiquitous family of chaperones that protect unfolded proteins from irreversible aggregation in the cell. Human sHSPs are associated with the pathology of a variety of diseases. The ...
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(2016-11-30)Department: Molecular Physiology and BiophysicsThe pleiotropic cytokine interleukin 2 (IL2) disrupts the blood-brain barrier and alters brain microcirculation, underlying vascular leak syndrome that complicates cancer immunotherapy with IL2. The microvascular effects ...
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(2015-09-11)Department: Molecular Physiology and BiophysicsObjective: Obesity has become a major worldwide health issue over the past few years and often leads to insulin resistance (IR) and type 2 diabetes (T2D). Macrophage accumulation in adipose tissue (AT) during obesity ...
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(2010-12-13)Department: Molecular Physiology and BiophysicsThe goal of my dissertation project was to characterize interactions between the transactivator Rap1 and Taf subunits of the TFIID complex. This experimental problem falls under a larger umbrella of gene regulation, since ...
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(2006-11-13)Department: Molecular Physiology and BiophysicsHeart disease is the number one cause of death in the United States. There are many forms of heart disease including heart failure and arrhythmias. One underlying theme in heart disease and many other diseases is disrupted ...
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(2010-12-13)Department: Molecular Physiology and BiophysicsAll eukaryotic and some prokaryotic ClC anion transport proteins have extensive cytoplasmic C-termini containing two cystathionine-beta-synthase (CBS) domains. CBS domain secondary structure is highly conserved and consists ...
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(2011-09-01)Department: Molecular Physiology and BiophysicsRecent genome wide association (GWA) studies have linked single nucleotide polymorphisms (SNPs) in the G6PC2 gene with elevated fasting plasma glucose (FPG) and in the SLC30A8 gene with altered susceptibility to type 2 ...
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(2018-08-31)Department: Molecular Physiology and BiophysicsStress is a precipitating agent in neuropsychiatric disease and initiates relapse to drug-seeking behavior in addicted patients. Targeting the stress system in protracted abstinence from drugs of abuse with anxiolytics may ...
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(2009-06-15)Department: Molecular Physiology and BiophysicsThe bed nucleus of the stria terminalis (BNST) is a region of the brain critical in mediating behavioral and physiological responses to stress and anxiety. Stress is a major cause of relapse for drug addicts attempting ...
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(2016-11-03)Department: Molecular Physiology and BiophysicsElevated plasma triglycerides (TGs) increase risk of cardiovascular disease, especially in women. Estrogen treatment raises plasma TGs in women, but molecular mechanisms remain poorly understood. Here, I explore the role ...
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(2019-06-24)Department: Molecular Physiology and BiophysicsMOLECULAR PHYSIOLOGY AND BIOPHYSICS Contrast-Enhanced Optical Coherence Tomography Using Gold Nanorods Andrew Gordon Dissertation under the direction of Professor John S. Penn Optical coherence tomography (OCT) is ...
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(2014-06-30)Department: Molecular Physiology and BiophysicsAMP-activated protein kinase (AMPK) is a serine-threonine kinase that exerts control over mediators of metabolic flux. The structure of AMPK permits the sensing of changes in energy status. The dissertation examines the ...
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(2006-11-01)Department: Molecular Physiology and BiophysicsAdenovirus (Ad) vectors are promising vehicles for vaccine delivery and gene therapy, but vector development has been hampered by the lack of an atomic structure of the intact virion. In this work, cryoEM single particle ...
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(2018-08-15)Department: Molecular Physiology and BiophysicsRecent observations have challenged the long held concept that all β cells are eventually destroyed in type 1 diabetes (T1D). Indeed, many individuals with T1D produce small amounts of C-peptide long after disease onset ...
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(2019-03-22)Department: Molecular Physiology and BiophysicsKir7.1 is an inwardly rectifying potassium channel with important roles in the regulation of the membrane potential in retinal pigment epithelium, uterine smooth muscle, and hypothalamic neurons. Regulation of G protein–coupled ...
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(2007-07-31)Department: Molecular Physiology and BiophysicsMOLECULAR PHYSIOLOGY AND BIOPHYSICS DOPAMINE DEPLETION ALTERS THE BALANCE BETWEEN CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE II AND PROTEIN PHOSPHATASE I ABIGAIL M. BROWN Dissertation under the direction of Professor ...
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(2012-12-11)Department: Molecular Physiology and BiophysicsInsulin secretion is the natural response to hyperglycemia, and it is crucial to maintain glucose homeostasis in healthy individuals. Impairment in this regulation eventually results in Type-2 diabetes. From the perspective ...
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(2007-08-02)Department: Molecular Physiology and BiophysicsThe transcription factor Pdx1 is expressed throughout the pancreas early, but selectively in insulin-producing cells postnatally. Previous studies showed that conserved regulatory regions, Areas I and II (Pdx1PB), directed ...
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(2012-03-29)Department: Molecular Physiology and BiophysicsObesity is closely linked to many metabolic diseases such as insulin resistance (IR), type 2 diabetes mellitus and cardiovascular disease. In the past decade, it has been established that immune cells are recruited to ...
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(2018-07-22)Department: Molecular Physiology and BiophysicsThe phagocytic nature and oxidative resiliency of macrophages not only allows them to function as innate immune cells but also to respond to specific tissue needs, such as iron homeostasis. MFehi ATMs are a subtype of ...