Browsing Electronic Theses and Dissertations by Department "Microbiology and Immunology"
Now showing items 1-20 of 126
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(2016-11-23)Department: Microbiology and ImmunologyStaphylococcus aureus is a Gram-positive pathogen that contributes to significant morbidity and mortality worldwide. In order to successfully colonize the host, S. aureus requires heme as a nutrient iron source and as a ...
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(2018-03-29)Department: Microbiology and ImmunologyThe immune system is a complex network of cells spread throughout the body, spanning dozens of tissue types and locations. A complete understanding of a systemic immune response, like those required for the regression of ...
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(2011-07-29)Department: Microbiology and ImmunologyAPOBEC3G (A3G) is a cytidine deaminase that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in the absence of the HIV-1 virion infectivity factor (Vif) protein. However, in the presence of the viral ...
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(2011-08-17)Department: Microbiology and ImmunologyPopulations of amphibians around the world have experienced devastating declines in the last few decades. A newly emerging fungal pathogen, Batrachochytrium dendrobatidis, has been implicated as one cause of these declines. ...
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(2016-07-29)Department: Microbiology and ImmunologySeasonal influenza remains a worldwide health concern and recently, the novel avian influenza virus, H5N1, has infected and caused disease in humans, though the virus is not currently capable of human-to-human transmission. ...
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(2015-02-11)Department: Microbiology and ImmunologyCoronaviruses are positive-sense RNA viruses that cause significant diseases in humans. Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) caused a pandemic in 2002-2003, and Middle East Respiratory Syndrome coronavirus ...
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(2006-05-18)Department: Microbiology and ImmunologyAutoimmune and atopic diseases are immune-mediated multigenic diseases. The work of this thesis tests the hypothesis of performing gene expression profiling using peripheral blood mononuclear cells as a common source to ...
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(2008-07-16)Department: Microbiology and ImmunologyThe á2â1 integrin is expressed on many cell types throughout the immune system. Expression of the á2â1 integrin on mast cells is required for the early innate immune response to Listeria monocytogenes. Interaction between ...
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(2010-03-02)Department: Microbiology and ImmunologyCoronaviruses belong to a family of enveloped, positive-strand RNA viruses that cause a multitude of devastating diseases in both animals and humans. Like other positive-strand RNA viruses, coronaviruses utilize several ...
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(2006-10-09)Department: Microbiology and ImmunologySelf-reactive B lymphocytes are frequently produced as a consequence of B cell antigen receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by tolerance mechanisms survive and mature in the ...
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(2012-12-07)Department: Microbiology and ImmunologyThis project is concerned with how the recently discovered paramyxovirus, human metapneumovirus (HMPV), interacts with host cells to initiate entry. In this dissertation I explore whether the HMPV fusion protein interacts ...
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(2017-03-31)Department: Microbiology and ImmunologyBruton’s tyrosine kinase (BTK) is a tec-family kinase present in B lymphocytes and innate immune cells. BTK is an important regulator of B cell autoreactivity. Innate-like autoreactive-prone B1, anergic An1, and transgenic ...
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(2013-12-03)Department: Microbiology and ImmunologyMy thesis project explores mechanisms controlling CD8+ T cell impairment in the lung during viral acute lower respiratory infection. I show that viral infection is required for lung T cell impairment and that cognate viral ...
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(2014-08-04)Department: Microbiology and ImmunologyCoronaviruses (CoVs) are positive-strand RNA viruses that induce modifications to host-cell cytoplasmic membranes during formation of replication complexes. While important for viral replication, the dynamics of this process ...
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(2006-08-09)Department: Microbiology and ImmunologyMICROBIOLOGY AND IMMUNOLOGY CHARACTERIZATION OF AN AUTOIMMUNE GENE EXPRESSION SIGNATURE KEVIN MAAS Dissertation under the direction of Professor Thomas Aune Autoimmune diseases affect approximately 5% of the human ...
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(2017-10-20)Department: Microbiology and ImmunologyCytomegalovirus (CMV) infection or latency reactivation is usually asymptomatic except in immune-suppressed hosts where it causes end-organ complications. CMV has also been proposed to drive cardiovascular disease in ...
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(2011-04-29)Department: Microbiology and ImmunologyHIV-epitope-specific T cell responses are critical components of the natural immune response to HIV infection, but these cells often become dysfunctional in chronic infection. Structural diversity within the epitope-specific ...
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(2018-03-22)Department: Microbiology and ImmunologyCeliac disease is an immune-mediated intestinal disorder that occurs in genetically predisposed individuals exposed to dietary gluten. Viral infections are associated with the induction of celiac disease. However, not all ...
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(2017-11-30)Department: Microbiology and ImmunologyThe goal of this thesis was to investigate the role of the IsdG family of heme oxygenases within microbial cells. In Chapter II, I identified the first IsdG family member in a eukaryotic organism and expanded the IsdG ...
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(2019-03-22)Department: Microbiology and ImmunologyUrinary tract infections (UTIs) are very common, the disease severity can encompass a broad range of clinical diagnoses, including acute cystitis, pyelonephritis, catheter-associated infection, and asymptomatic bacteriuria. ...