Browsing Electronic Theses and Dissertations by Department "Cell & Developmental Biology"
Now showing items 1-20 of 42
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(2022-02-16)Department: Cell & Developmental BiologyWhen an organism is injured, the damaged tissue recognizes the presence and severity of the wound and rapidly responds to repair the injury and restore proper tissue functionality. But how do cells first detect the presence ...
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(2020-01-17)Department: Cell & Developmental BiologyBasement membranes are sheet-like extracellular matrixes that can be found on the basal surface of epithelial and endothelial cells, surrounding muscles and other organs, and in association with neurons. In addition to ...
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(2022-05-16)Department: Cell & Developmental BiologyThe ventral actin cytoskeleton is a dynamic network of actin stress fibers (VSFs) and focal adhesions that produces contractile forces integral in cell polarization, migration and extracellular matrix remodeling. My research ...
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(2020-07-22)Department: Cell & Developmental BiologyHere, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences ...
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(2021-06-15)Department: Cell & Developmental BiologyMulticellular organisms adapt to the environment by sensing it and reacting to it through neuronal networks that are in place to transform a stimulus into a behavioral effect. A functional nervous system requires pruning ...
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(2023-04-10)Department: Cell & Developmental BiologyMicrovilli are actin-based surface protrusions that have been repurposed throughout evolution to fulfill diverse cell functions including mechanosensation in inner ear hair cells and nutrient absorption in transporting ...
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(2021-04-02)Department: Cell & Developmental BiologyCancer is a heterogeneous disease displaying a variety of cell populations inter- and intra-tumorally. This heterogeneity poses a challenge to cancer treatment, as more heterogeneous cellular populations are more prone to ...
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(2021-11-19)Department: Cell & Developmental BiologyDiabetic retinopathy (DR) is the leading cause of blindness in working age Americans. Chronic low-grade retinal inflammation is an essential contributor to the pathogenesis of DR, as it is known to drive many of the ...
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(2023-08-31)Department: Cell & Developmental BiologyThe ductus arteriosus (DA) is a muscular artery which helps to define the fetal pattern of the circulatory system. After birth, the DA undergoes muscular constriction and remodeling which establish the adult division between ...
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(2023-01-20)Department: Cell & Developmental BiologyMicrovilli are actin-bundle-supported surface protrusions that play essential roles in diverse epithelial functions, from nutrient absorption to mechanosensation. Despite the importance of microvilli for proper epithelial ...
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(2021-06-08)Department: Cell & Developmental BiologyDynamics and Regulation of Microtubule Minus Ends Microtubules are an integral part of the cytoskeletal system in cells and serve essential roles in cell division, intracellular transport, and morphogenesis. Microtubules ...
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(2022-02-16)Department: Cell & Developmental BiologyThe brain is one of the most complex and mysterious organs in the human body. Centuries of research have shown that it is generated by a finely orchestrated series of events that take place in the first weeks of life up ...
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(2022-03-17)Department: Cell & Developmental BiologyRhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic ...
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(2023-03-29)Department: Cell & Developmental BiologyIn pancreatic beta cells, molecular motors use cytoskeletal polymers microtubules as tracks for intracellular transport of secretory insulin granules. Beta-cell microtubule network has a complex architecture, which allows ...
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(2021-01-06)Department: Cell & Developmental BiologyEpithelial cells possess intrinsic mechanisms to maintain an appropriate cell density for normal tissue morphogenesis and homeostasis. Defects in such mechanisms likely contribute to hyperplasia and cancer initiation. To ...
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(2021-05-13)Department: Cell & Developmental BiologyThe body of work presented in this dissertation details the characterization of a novel human-cell derived model of the understudied, non-canonical cullin scaffold CUL9. Unlike other cullins, previous efforts to characterize ...
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(2023-07-18)Department: Cell & Developmental BiologyEye development is a delicate process requiring a balance of genes and proteins expressed over the correct time course. Disruptions in the expression of essential genes are detrimental to vision. The transcription factor ...
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(2020-06-16)Department: Cell & Developmental BiologyHuman casein kinase 1 delta (CK1δ) and epsilon (CK1ε) are members of a conserved family of ubiquitously expressed serine/threonine kinases that regulate multiple cellular processes including endocytosis, circadian rhythm, ...
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(2022-03-29)Department: Cell & Developmental BiologyThe microtubule network in cells continuously remodels to facilitate its vital functions in cell division, cell motility and intracellular transport. Organization of the microtubule network is enabled by regulation of the ...
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(2023-11-16)Department: Cell & Developmental BiologyActin-based protrusions are found on the surface of all eukaryotic cells, where they support diverse biological activities essential for life. Models of protrusion growth hypothesize that actin filament assembly provides ...