Browsing Electronic Theses and Dissertations by Author "W. David Merryman"
Now showing items 1-11 of 11
-
Boronyak, Steven Michael (2015-07-01)Department: Biomedical EngineeringCurrent treatment for moderate and severe mitral regurgitation (MR), due to degenerative mitral valve (MV) disease, is open-chest surgical repair or replacement, as there are no known pharmacologic therapies that directly ...
-
Boronyak, Steven Michael (2012-04-05)Department: Biomedical EngineeringMitral valve prolapse is one subtype of mitral valve disease and is characterized by enlarged leaflets that are often thickened and have disrupted collagen architecture. The increased surface area of leaflets with mitral ...
-
Schroer, Alison Koelle (2014-03-27)Department: Biomedical EngineeringFibrotic disease is a major cause of morbidity and mortality and is characterized by the transition of resident fibroblast cells into active myofibroblasts, identified by their expression of alpha smooth muscle actin. ...
-
Bowler, Meghan Allardyce (2018-04-11)Department: Biomedical EngineeringCalcific aortic valve disease affects a quarter of those over 65 in the US alone. The only treatment is aortic valve replacement, but this intervention carries with it a high rate of morbidity and mortality and is often a ...
-
Schroer, Alison Koelle (2016-11-22)Department: Biomedical EngineeringHeart disease is a leading cause of death worldwide, and many cardiac conditions that contribute to high morbidity and mortality are characterized by tissue fibrosis and maladaptive remodeling. Build-up of extracellular ...
-
Sewell-Loftin, Mary Kathryn (2014-04-01)Department: Biomedical EngineeringNearly 300,000 heart valve (HV) replacement surgeries are performed annually, including both pediatric patients with valvular defects and elderly patients suffering from degenerative or calcific valve diseases. Worldwide, ...
-
Hendrick, Richard Joseph (2017-07-20)Department: Mechanical EngineeringThe motivation for this dissertation is to provide surgeons with more capable tools during minimally invasive surgery. Specifically, this work is focused on the design of robotic systems that provide flexible, multi-arm ...
-
D'Amico, Reid William (2018-07-19)Department: Biomedical EngineeringEndothelial dysfunction is a known consequence of Bone Morphogenetic Protein Receptor Type II (BMPR2) mutations in pulmonary arterial hypertension (PAH). Initial studies aimed to prevent heritable PAH by inhibiting the ...
-
Bloodworth, Nathaniel Craig (2017-06-28)Department: Biomedical EngineeringPulmonary arterial hypertension (PAH) is a deadly, insidious illness of the pulmonary vasculature with no effective treatment. Until the mechanisms that drive disease progression and small vessel remodeling are better ...
-
Hutcheson, Joshua Daniel (2012-08-31)Department: Biomedical EngineeringAortic valve disease (AVD) is the third leading cause of cardiovascular disease and is especially prevalent among the elderly. In AVD, thickened fibrotic AV leaflets lose their ability to fully open and close, causing ...
-
Chen, Joseph (2015-03-26)Department: Biomedical EngineeringCalcific aortic valve disease (CAVD) is the predominant valvular disease in the developed world, affecting over five million individuals in the United States alone and manifests itself as a progressive disease resulting ...