Browsing Electronic Theses and Dissertations by Author "H. Scott Baldwin"
Now showing items 1-14 of 14
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Bennett, Jeffrey Scott (2013-06-17)Department: Human GeneticsA BIPHASIC ROLE FOR THE VOLTAGE-GATED SODIUM CHANNEL SCN5LAB IN CARDIAC DEVELOPMENT OF ZEBRAFISH JEFFREY S. BENNETT Dissertation under direction of Professor Dan M. Roden, M.D. Voltage-gated sodium channels (VGSCs) play ...
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Bylund, Jeffery B. (2017-04-05)Department: PharmacologyHeart development depends on coordinated proliferation and differentiation of cardiac progenitor cells, but how the two processes are synchronized is not well understood. The data herein show that the secreted BMP antagonist ...
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Paik, David Tohyun (2015-12-04)Department: Cell and Developmental BiologyMyocardial infarction (MI) causes irreversible tissue damage, leading to heart failure. Our laboratory found canonical Wnt signaling and the Wnt10b ligand are strongly induced in mouse and human hearts after MI. Wnt10b ...
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Misfeldt, Andrew Michael (2008-12-30)Department: Cell and Developmental BiologyIdentification of multipotent cardiac progenitors has provided fresh insight into the mechanisms of myocardial lineage specification, yet has done little to clarify the origin of the endocardium. Despite its essential role ...
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Fioret, Bryan Adam (2014-07-03)Department: PharmacologyCardiac tissue undergoes renewal with low rates. Although resident stem cell populations have been identified to support cardiomyocyte turnover, the source of the cardiac stem cells and their niche remain elusive. Using ...
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Feaster, Tromondae Kenta (2015-11-18)Department: PharmacologyHuman induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) have the potential to be an important tool for cardiovascular disease modeling, pre-clinical cardiotoxicity evaluation, and drug discovery. However, ...
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DeLaughter, Daniel Morris (2013-06-10)Department: Cell and Developmental BiologyEpithelial-to-Mesenchymal Transformation (EMT) is an important process in development, and occurs during key steps in both valvular and coronary vessel development. This dissertation uses transcriptional profiling strategies ...
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Cross, Emily Elizabeth (2012-01-26)Department: Cell and Developmental BiologyEpicardial development is a complex process that involves tightly regulated coordination of concurrent cellular behaviors ranging from sheet migration to secretion. The regulation of these behaviors is poorly understood, ...
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Chen, Joseph (2015-03-26)Department: Biomedical EngineeringCalcific aortic valve disease (CAVD) is the predominant valvular disease in the developed world, affecting over five million individuals in the United States alone and manifests itself as a progressive disease resulting ...
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Boyle, Scott Clifford (2007-08-02)Department: Cell and Development BiologyKidney development in mammals is characterized by reciprocal tissue interaction between the ureteric bud and the metanephric mesenchyme. The outgrowing epithelial bud invades the overlying mesenchyme, inducing epithelial ...
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Pooley, Ryan Dee (2006-12-04)Department: Cell and Developmental BiologySNAP-25 and syntaxin 4 are SNARE proteins that are involved in membrane transport. In order for proteins to traffic properly through membranous organelles, a series of budding and fusion events must occur between donor and ...
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Langworthy, Melissa Marie (2008-04-14)Department: Cell and Developmental BiologyRecovery from acute kidney injury (AKI) requires renal tubule cell regeneration. The population of cells that repair the damaged proximal tubule epithelial cells (PTC) has been proposed to be derived from an external ...
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Chiba, Takuto (2015-06-05)Department: Cell and Developmental BiologyRetinoic acid (RA) has been used therapeutically to reduce injury and fibrosis in models of acute kidney injury (AKI), but little is known about whether and how this pathway is normally regulated, and what role it plays ...
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Woo, Kel Vin (2010-07-12)Department: Cell and Developmental BiologyAlthough it is known that the response of endothelial cells to atherogenic disturbed flow is distinct from that elicited by non-atherogenic laminar flow, the mechanisms involved are poorly understood. Observing that ...