Browsing Electronic Theses and Dissertations by Author "H. Charles Manning"
Now showing items 1-12 of 12
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Ortega, Ryan Adam (2010-12-06)Department: Biomedical EngineeringThe goal of this work is to develop and demonstrate a novel model of superparamagnetic iron oxide nanoparticle (SPION) magnetic properties based on physical first principles and experimental mathematical relationships. ...
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Whisenant, Jennifer Gray (2013-07-29)Department: Chemical and Physical BiologyWith the development of anti-cancer therapies that specifically target the tumor and its microenvironment, the current radiographic analysis of treatment response that uses one-dimensional changes in tumor size may not be ...
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Shah, Amy Trushar (2013-12-02)Department: Biomedical EngineeringOptical metabolic imaging measures fluorescence intensity and lifetimes from metabolic cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD). These molecular level measurements provide ...
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Walsh, Alexandra Jule (2015-03-11)Department: Biomedical EngineeringA clinical need exists for improved methods to identify cancer patients with tumors prone to drug resistance, and prescribe effective alternative therapies. Cellular metabolism is a powerful marker of tumor response to ...
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Hariri, Ghazal (2014-12-03)Department: Chemical and Physical BiologyCurrent chemotherapeutic treatments for cancer utilize systemic administration of cytotoxic drugs and produce many side effects in healthy tissues, making optimal treatment of cancer hard to achieve. Tumor targeted ...
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Mutic, Nathan James (2009-12-14)Department: Chemical and Physical BiologyPositron emission tomography (PET) imaging using the radiotracer 3’-deoxy-3’-[18F]fluorothymidine ([18F]-FLT) has shown potential as a biomarker of proliferation in tumors. [18F]-FLT measures the activity of thymidine ...
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McKinley, Eliot Thomas (2013-04-15)Department: Biomedical EngineeringBiomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. With an increasing reliance on molecularly targeted therapies, there remains an equally critical challenge ...
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Johnson, Rachelle Whitney (2011-08-30)Department: Cancer BiologyBreast cancer frequently metastasizes to the skeleton with severe consequence to patient quality of life. Patients who develop bone metastases suffer from severe bone pain and increased risk of developing hypercalcemia ...
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Li, Jun (2016-07-13)Department: Interdisciplinary Materials ScienceTranslocator protein (TSPO) represents an attractive target for molecular imaging and therapy due to its prevalence and critical roles played in oncology and other pathologies. Based upon our previously optimized ...
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Shah, Amy Trushar (2016-06-06)Department: Biomedical EngineeringOptimized therapies and methods to resolve treatment response could improve quality of life and survival for head and neck cancer patients. Optical metabolic imaging presents an advantageous method to address these needs ...
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Hight, Matthew Roland (2014-11-25)Department: Interdisciplinary Materials ScienceMitochondrial homeostasis serves as a ‘gate-keeper’ for a cell’s viability and plays key regulatory roles in apoptotic cell death, metabolism, reactive oxygen species accumulation/defense, and various biosynthetic pathways. ...
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Use of 18FDG-PET imaging to predict treatment response to IGF-1R/IR targeted therapy in lung cancer McKinley, Eliot Thomas (2011-04-14)Department: Biomedical EngineeringThe use of 18FDG-PET imaging to predict treatment response to IGF-1R/IR targeted therapy in mouse models of human lung cancer is presented in this thesis. In vitro cell studies were first conducted to establish sensitivity ...