Browsing Electronic Theses and Dissertations by Author "H. Alex Brown"
Now showing items 1-17 of 17
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Kliman, Michal (2011-08-02)Department: ChemistryIon mobility-mass spectrometry (IM-MS) provides rapid (μs-ms) two dimensional separations on the basis of molecular structure and mass-to-charge (m/z), respectively. Based on differences in intramolecular packing of various ...
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O'Reilly, Matthew Charles (2014-06-26)Department: ChemistryMy doctoral research has focused on (i) using organocatalysis to prepare enantioenriched pharmaceutically relevant scaffolds and (ii) preparing isoenzyme selective inhibitors of phospholipase D. (i) Methodologies for ...
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Tomasiak, Thomas (2011-02-21)Department: PharmacologyComplex II superfamily members catalyze two separate reactions in respiration: interconversion of fumarate and succinate in the soluble milieu and interconversion of quinol and quinone in the membrane. Electrons liberated ...
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Burnum, Kristin Elizabeth (2008-12-03)Department: BiochemistryMolecular events involved in successful embryo implantation take place in defined time and space but are not generally well understood. Here for the first time, we use MALDI Imaging Mass Spectrometry (IMS) technologies ...
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Yu, Zheyong (2005-10-19)Department: PharmacologyLipoxygenase (LOX) are non-heme iron dioxygenases that form fatty acid hydroperoxides used in membrane remodeling and cell signaling. Mammalian epidermal LOX type 3 (eLOX3) is distinctive in totally lacking this typical ...
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Manna, Joseph Dominick (2014-07-03)Department: Chemical and Physical BiologyProstaglandin glycerol esters (PG-Gs) are produced by the oxygenation of the endocannabinoid, 2-arachidonoylglycerol, by cyclooxygenase 2. Understanding the role that PG-Gs play in a biological setting has been difficult ...
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Bruntz, Ronald Chase (2014-02-11)Department: PharmacologyThe production of bioactive lipids by phospholipases has long been appreciated as an important mode of cellular communication. Phospholipase D (PLD) enzymes hydrolyze phosphatidylcholine to generate a choline headgroup and ...
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Henage, Lee Gardner (2006-03-30)Department: PharmacologyIn mammalian cells, phospholipase D activity is tightly regulated by diverse cellular signals including hormones, neurotransmitters, and growth factors. Multiple signaling pathways converge upon phospholipase D to modulate ...
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Selvy, Paige Elizabeth (2011-11-11)Department: PharmacologyIncreasing evidence supports an integral role for the lipid second messenger phosphatidic acid (PtdOH) in cell signaling. In addition to altering curvature of biological membranes, PtdOH lies at the intersection between ...
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Young, Summer Elizabeth (2013-12-03)Department: PharmacologyThe platelet thrombin receptors Protease-activated receptor 1 (PAR1) and Protease activated receptor 4 (PAR4) stand at the intersection of coagulation and platelet activation. Thrombin receptors are thus excellent ...
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Coffa, Sergio (2011-08-05)Department: PharmacologyArrestins are multifunctional signaling proteins, important for the regulation of signal transduction and the trafficking of G protein-coupled receptors (GPCRs). Recently, GPCR-arrestin interactions have been proposed to ...
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Zeng, Xin-Xin I. (2008-02-15)Department: Biological SciencesProper embryonic development requires precise cell movements, which are coordinated by multiple signaling pathways. Formation of specific organs is initiated during gastrulation when organ precursors acquire their initial ...
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Jernigan, Kristin Kalie (2010-04-05)Department: Cell and Developmental BiologyThe Wnt/beta-catenin signaling pathway is a well-conserved signal transduction pathway that is highly regulated during metazoan development and is associated with various human diseases. In the current model of Wnt/beta-catenin ...
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Huang, Fude (2006-04-04)Department: Biological SciencesThe temperature-sensitive (TS) paralyzed and blind Drosophila mutant rolling blackout (rbo) identifies a gene encoding a protein that pioneers a novel family of membrane-associated putative lipolytic enzymes highly conserved ...
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Hermanson, Daniel John (2014-04-08)Department: ChemistrySubstrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects. Daniel John Hermanson Dissertation under the direction of Professor Lawrence J. Marnett Cyclooxygenase-2 ...
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Lavieri, Robert Raymond (2014-11-06)Department: PharmacologyPhospholipase D (PLD) catalyzes the production of the lipid second messenger phosphatidic acid (PtdOH). PLD expression and/or enzymatic activity are both elevated in a variety of human cancers. Inhibition of PLD enzymatic ...
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Beavers, William Norris (2015-07-21)Department: ChemistryPolyunsaturated Fatty Acids (PUFAs) are oxidized both enzymatically and by autoxidation to many inflammatory signaling molecules, which have been detected in multiple disease states. Oxidized PUFAs can further react to ...