Browsing Electronic Theses and Dissertations by Author "F. Peter Guengerich"
Now showing items 1-11 of 11
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Nannemann, David Patrick (2011-04-06)Department: ChemistryNucleoside analogs comprise a large therapeutic class applied to the treatment of HIV, hepatitis, and other diseases. Their broad use and applicability are in contrast to their high manufacturing cost. Given the similarity ...
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Branch, Megan Christine (2011-07-07)Department: BiochemistryGenome sequencing projects have revealed that glutathione (GSH) transferases are widely distributed in bacteria but most remain only as annotations in sequenced genomes. The goal of this project was to assign function to ...
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Xiao, Yi (2014-09-16)Department: BiochemistryCytochrome P450s are versatile biocatalysts that play crucial roles in many important biological processes. Functional annotation of orphan P450 enzymes is the focus of this work. Catalytic activities of orphan human P450 ...
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Schavolt, Kristy Lynn (2006-12-07)Department: BiochemistryBIOCHEMISTRY IDENTIFICATION AND REGULATION OF P53 TARGET GENES IN PRIMARY HUMAN EPIDERMAL KERATINOCYTES KRISTY L. SCHAVOLT Dissertation under the direction of Professor Jennifer A. Pietenpol The p53 tumor suppressor ...
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Garmendia, Craig Alexander (2008-12-15)Department: ChemistryExposure to endogenous and exogenous chemicals can lead to modification of DNA and potentially lead to cancer. Frameshift mutations may be a consequence of these modifications to DNA. Oligonucleotides were synthesized ...
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Agostini, Maria (2019-10-17)Department: Microbiology and ImmunologyEmerging viruses, such as coronaviruses (CoVs), continue to pose a threat to human health, and few countermeasures have been approved to treat these infections. Two CoVs have emerged to cause severe disease in humans within ...
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Sohl, Christal Dyane (2010-06-23)Department: BiochemistryThe kinetic characterization of cytochrome P450s that catalyze multi-step, sequential reactions is the focus of this work. Two novel substrates were identified for P450 1A2, one of which showed a high degree of homotropic ...
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Duggan, Kelsey Constance (2011-01-14)Department: BiochemistryThe cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion arachidonic acid (AA) to prostaglandin H2 (PGH2), which is the precursor to biologically active prostanoids. The primary mechanism of action of non-steroidal ...
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Brown, Kyle Lamar (2008-06-06)Department: ChemistryThis dissertation involves the structural and equilibrium studies of three DNA lesions: aflatoxin B1 formamidopyrimidine, methyl formamidopyrimidine, and thymine glycol. Studies of the methyl formamidopyrimidine ...
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Albertolle, Matthew Edward (2019-01-30)Department: BiochemistryMammalian cytochrome P450 (P450) enzymes catalyze complex reactions involved in the biosynthesis of endogenous metabolites such as steroids, vitamins, and hormones. Additionally, several enzymes in this superfamily are ...
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Zheng, Yuxiang (2010-12-10)Department: PharmacologyThe goal of my thesis research is to elucidate the catalytic mechanism and physiological function of the atypical mammalian lipoxygenase, epidermal lipoxygenase-3. Although named as a lipoxygenase based on sequence homology ...