Browsing Electronic Theses and Dissertations by Author "D. Brent Polk"
Now showing items 1-5 of 5
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Muñoz, Nina Margarita (2006-12-01)Department: Cancer BiologyTransforming Growth Factor-β (TGF-β) is a cytokine involved in the regulation of multiple cellular responses, and it is accepted that the TGF-β signaling pathway is implicated in both tumor-suppressing and tumor-promoting ...
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Dise, Rebecca Susanne (2006-04-20)Department: Cell and Developmental BiologyThe lining of the gastrointestinal tract, a single layer of epithelial cells, forms a dynamic barrier that protects the organism from harmful substances present in the lumen. Maintenance of a healthy gastrointestinal tract ...
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Goettel, Jeremy Allen (2010-08-03)Department: Cell and Developmental BiologyOne Immunological disorders of the gastrointestinal tract is inflammatory bowel disease (IBD). IBD results in recurrent and persistently elevated levels of cytokines, such as tumor necrosis factor (TNF). TNF promotes ...
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Raf-1 kinase regulates intestinal epithelial cell survival in response to pro-inflammatory stimuli Edelblum, Karen Leigh (2008-04-08)Department: Cell and Developmental BiologyThe maintenance of the intestinal epithelium is dependent upon controlled regulation of cell proliferation and apoptosis, or programmed cell death. Dysregulation of either of these processes can compromise the integrity ...
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Hilliard, Valda Catherine (2011-08-02)Department: Cell and Developmental BiologyDisruption of intestinal epithelial homeostasis, including enhanced apoptosis, is a hallmark of inflammatory bowel disease (IBD). We have shown that tumor necrosis factor (TNF) increases the kinase activity of ErbB4, a ...