Browsing Electronic Theses and Dissertations by Author "C. David Weaver"
Now showing items 1-6 of 6
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Discovery and characterization of G protein-gated, inwardly-rectifying, potassium channel modulators Kozek, Krystian Andrzej (2018-10-16)Department: PharmacologyG protein-gated, inwardly-rectifying, potassium (K+) (GIRK) channels are important regulators of cellular excitability throughout the body. GIRK channels are composed of four subunits and exist as homomeric and heteromeric ...
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Kumar, Kevin Krishan (2014-08-29)Department: NeuroscienceManganese (Mn) is both an essential biological cofactor and neurotoxicant. Disruption of Mn biology in the basal ganglia has been implicated in the pathogenesis of neurodegenerative disorders, such as parkinsonism and ...
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Mueller, Ralf (2011-08-03)Department: ChemistryThe focus of this work was to establish quantitative structure activity (QSAR, potency of allosteric modulators) and property (QSPR, carbon chemical shifts) relations for molecules with known structure and activity/property ...
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Raphemot, Rene (2014-05-28)Department: PharmacologyInward rectifier potassium (Kir) channels are a family of two transmembrane-spanning potassium selective ion channels. Kir channels are found in all kingdoms of life where they play essential roles in regulating numerous ...
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Wong, Alexis Camille (2017-07-31)Department: ChemistryGold nanoparticles conjugated to short sensing strands of DNA have been successfully applied to therapeutic silencing and intracellular detection of disease-associated mRNAs. These biomedical applications are possible ...
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Azumaya, Caleigh Mariko (2018-12-19)Department: Molecular Physiology and BiophysicsGlutamatergic neurotransmission is a set of signal cascades that result in propagation of the action potential from the presynaptic to the postsynaptic neuron. There are fast signals controlled by the ionotropic glutamate ...