Browsing Electronic Theses and Dissertations by Title
Now showing items 5516-5535 of 6747
-
(2019-10-15)Department: Microbiology and ImmunologyNaïve CD4+ T cells polarize into many varied CD4+ T-helper (TH) cell subsets depending on the cytokine milieu present during T cell receptor stimulation. Each T cell subset produces a unique cytokine profile to defend ...
-
(2023-07-15)Department: SociologyDespite its significant growth globally over the past two decades, the single and living alone (SALA) population remains understudied. This study asks how SALA status impacts health and how its impact varies by social ...
-
(2007-03-31)Department: SociologyThis study explores how emotion culture relates to class position and beliefs about masculinity. What are the cultural ideologies, values, norms, and vocabularies about emotion that structure men’s lives? And, do these ...
-
(2015-11-24)Department: Political ScienceUnder what circumstances do citizens turn to their neighbors to confront criminals directly? I propose that social capital and distrust in authorities interact to increase the probability that citizens will attempt to ...
-
(2013-07-29)Department: Cell and Developmental BiologyMy study of three signaling pathways in the context of three gastrointestinal diseases is presented here. Firstly, the epidermal growth factor receptor (EGFR) pathway and its role in the pathogenesis of the hypertrophic ...
-
(2017-11-27)Department: BiostatisticsHormonal therapy adherence is challenging for many patients with hormone-receptor-positive breast cancer. Gaining intuition into their adherence behavior would assist in improving outcomes by pinpointing, and eventually ...
-
(2017-10-16)Department: Learning, Teaching and DiversityThough researchers and policymakers have called for an increase in text complexity in reading instruction, little research exists on whether scaffolding can support students reading complex texts, and almost no research ...
-
(2011-08-16)Department: EnglishIn 1606, an Act was passed in the English Parliament that prohibited speaking the name of God or the Holy Trinity onstage. This paper examines the anxieties that this Act revealed, particularly anxieties over the use and ...
-
(2021-08-09)Department: FrenchTant ai fet mal: Reflections on Violence in the Old French Cycle of Guillaume d'Orange Anthony Gerardo Contreras Dissertation under the direction of Professor Lynn Ramey This dissertation investigates the complex role ...
-
(2022-03-27)Department: Chemical EngineeringIn this dissertation, multiple investigations targeting specific reaction centers of the Photosystem I (PSI) protein complex were performed. Historically, PSI has been used and analyzed in three-electrode electrochemical ...
-
(2020-03-11)Department: Chemical EngineeringThe blood-brain barrier (BBB) is formed by endothelial cells that line brain vasculature and separate the blood stream and central nervous system parenchyma. The BBB functions as an exceptionally dynamic molecular gatekeeper, ...
-
(2018-07-19)Department: Biomedical EngineeringEndothelial dysfunction is a known consequence of Bone Morphogenetic Protein Receptor Type II (BMPR2) mutations in pulmonary arterial hypertension (PAH). Initial studies aimed to prevent heritable PAH by inhibiting the ...
-
(2017-06-28)Department: Biomedical EngineeringPulmonary arterial hypertension (PAH) is a deadly, insidious illness of the pulmonary vasculature with no effective treatment. Until the mechanisms that drive disease progression and small vessel remodeling are better ...
-
(2013-09-04)Department: Cancer BiologyThe overall survival for neuroblastoma remains dismal, in part due to the emergence of resistance to chemotherapeutic drugs resulting in aggressive, refractory disease. As a neuroendocrine tumor, neuroblastomas secrete a ...
-
(2021-03-29)Department: Cancer BiologyBone is a common site of metastasis for advanced breast, prostate, and lung cancer. Most patients with skeletal metastases develop tumor-induced bone disease (TIBD), which is characterized by a vicious cycle of tumor growth ...
-
(2015-11-24)Department: PharmacologyMalignant cancers are the second leading cause of death in the United States, with a projected 1.6 million new diagnoses per year and almost 600,000 deaths. Our understanding of the molecular pathways causing tumor initiation, ...
-
(2023-06-05)Department: PharmacologyInflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
-
(2023-06-05)Department: PharmacologyInflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
-
(2020-07-06)Department: Cancer BiologyThe mTOR kinase acts in two distinct complexes, mTORC1 and mTORC2, that sense environmental cues and coordinate downstream cellular processes. mTOR signaling is aberrantly regulated in many diseases including cancer. The ...
-
(2011-11-08)Department: Cancer BiologyDysregulation of the Notch signaling pathway plays an important role in lung cancer pathobiology. The Notch3 receptor is overexpressed in ∼40% of resected non-small cell lung cancers, and its suppression results in loss ...