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Experimental Evaluation of Advanced Diffusion MRI Methods Towards Improved Assessment of Myelinated Neural Tissue
(2017-02-09)
Diffusion-weighted MRI (DWI) techniques have demonstrated the ability to non-invasively assess normal and pathological neural tissue. Recently-developed advanced DWI methods have the potential to provide quantitative ...
Correction of image distortion in echo planar image series using phase and intensity
(2008-02-22)
Among all magnetic resonance imaging sequences, gradient-echo (GE) echo-planar imaging (EPI) has become the most common technique for the study of dynamic brain function and for other high-speed applications like cardiac ...
Quantitative proton relaxometry in the rotating frame with magnetic resonance imaging
(2011-08-30)
Conventional magnetic resonance imaging (MRI) uses contrast that is weighted by the intrinsic tissue parameters T1, and T2. Contrast may also be generated in the rotating frame with the analogous time constants T1ρ or T2ρ. ...
Diffusion Magnetic Resonance Imaging of the Human Spinal Cord in Vivo: Feasibility and Application of Advanced Diffusion Models
(2017-08-24)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is marked by inflammation, demyelination, gliosis and axonal loss. The damage to the CNS from these mechanisms can result in an ...
Intracranial Hemodynamic Compensation Mechanisms in Patients with Cerebrovascular Disease
(2017-09-25)
Cerebrovascular disease (CVD) encompasses conditions that affect the blood supply to the brain. CVD results in hemodynamic impairment, and when the brain can no longer compensate for decreased oxygen delivery to tissue, ...
High Resolution MRI of the Human Brain Using Reduced-FOV Techniques at 7 Tesla
(2011-08-08)
Achieving micron resolutions in magnetic resonance imaging is constrained first by limitations in available signal strength as voxel sizes decrease, and second, by acceptable acquisition times due to the large data sets ...
Multiple Echo, Caesar Cipher Acquisition and Model-Based Reconstruction (ME-CAMBREC): a Novel Accelerated T2 Mapping Method
(2016-11-07)
Due to the need to acquire a series of T2-weighted images, quantitative T2 mapping protocols in magnetic resonance imaging (MRI) suffer from long scan times. In order to alleviate this problem, fast spin-echo (FSE) imaging ...
Development and Characterization of NMR and MRI Methods for Assessment of Tumor Oxygen Consumption
(2012-10-08)
A common feature of invasive cancers is that they have an upregulation of glucose metabolism and reduced oxygen utilization. The overall goal of this research was to develop a 17Oxygen MRI method to access this aberrant ...
Validation of diffusion tensor imaging in the central nervous system using light microscopy
(2010-09-23)
Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on microscopic scales. To date, DTI is the only imaging method that provides such information in vivo, and it has proven to be a valuable tool ...
Development and Evaluation of Relaxation-Based Measures of Myelin Content and Microstructure in Rodent Brains
(2016-11-17)
Advanced neuroimaging techniques provide the possibility to non-invasively understand and monitor white matter during development and disease. While data from quantitative MRI techniques, such as multiexponential T2 (MET2) ...