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Mechanistically Distinct Modes of Endocannabinoid Mobilization at Glutamatergic Synapses of the Lateral Division of the Central Amygdala and Its Regulation by Chronic Stress
(2014-12-08)
The lateral division of the central amygdala (CeAL) is a key structure at the limbic-motor interface regulating stress-responses and emotional learning. Endocannabinoid (eCB) signaling is heavily implicated in the regulation ...
Biobehavioral Response to Social Judgment in Adolescents with Autism Spectrum Disorder
(2015-12-08)
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social behavior. It is unclear if deficits are due to disinterest in social stimuli, or to an elevated stress response. The ...
Reducing the Effect of Stress on Executive Control
(2020-06-18)
Previous research has shown that stress has a negative effect on executive control (Quinn & Joormann, 2015a, 2015b, 2020; Shields et al., 2016). The present study aimed to replicate the finding that a laboratory stressor ...
Metabotropic glutamate receptor mediated synaptic plasticity in the bed nucleus of the stria terminalis as a target for stress, anxiety and addiction disorders
(2006-01-20)
The importance of integration of information from neurocircuits innervating the reward circuitry is becoming increasingly recognized. For instance, the roles of stress/anxiety pathways in modulating specific effects of ...
Mothers Coping with Childhood Cancer in the Context of Sociodemographic Disadvantage: Interactive and Longitudinal Effects on Depressive Symptoms
(2017-02-20)
The present study integrated and expanded upon two previously separate lines of research on stress and coping processes endemic to mothers faced with two significant sources of stress: mothers coping with a child’s cancer ...
Reciprocal relations between peer stress and internalizing and externalizing symptoms during adolescence
(2004-07-30)
The purpose of this study was to examine the relations between peer stress and internalizing and externalizing symptoms across 4 years in adolescents whose risk for depression varied. The sample was comprised of 240 ...
The Effects of α2A-Adrenergic Receptors on Glutamatergic Signaling in the Bed Nucleus of the Stria Terminalis
(2014-09-10)
Drug addiction is a chronically relapsing disorder characterized by cycles of drug use, withdrawal, and relapse. Stress-induced relapse of drug use is a significant barrier to curing addiction. The bed nucleus of the stria ...
Dissecting the Stress Recruitment of BNST CRF Neurons: Regulation of Glutamatergic Inputs via Gi-coupled GPCR Signaling
(2018-09-18)
Stress contributes to numerous psychiatric disorders. CRF signaling in the bed nucleus of the stria terminalis (BNST) drives negative affective behaviors, thus agents that decrease activity of these cells may be of therapeutic ...
The role of chronotype and sleep disturbance in obsessive-compulsive disorder: A multimethod approach
(2021-08-03)
Previous research has found links between delayed circadian timing, sleep disturbance, and psychopathology. However, the role of sleep and circadian rhythm disruption in obsessive-compulsive disorder (OCD) remains unclear. ...
Eliminating Trauma Gatekeeping: Racial Trauma as a Mental Health Crisis
(2022-07-21)
Race based stress, also known as racial trauma, is defined as significant distress due to real or perceived racial discrimination. These can include threats to harm and/or injure, shaming and humiliation, and being witness ...